ArticleScientific reports2015
Urinary neutrophil gelatinase-associated lipocalin is associated with heavy metal exposure in welding workers.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Adverse Effects of fine particulate matter on human kidney functioning: a systematic review.Environmental health : a global access science source · 2022Pooled it
- Vanadium exposure and kidney markers in a pediatric population: a cross-sectional study.Pediatric nephrology (Berlin, Germany) · 2025Article
- The spatiotemporal and paradoxical roles of NRF2 in renal toxicity and kidney diseases.Redox biology · 2025Review
- A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease.Clinical, cosmetic and investigational dermatology · 2025Article
- Metabolomics and proteomics in occupational medicine: a comprehensive systematic review.Journal of occupational medicine and toxicology (London, England) · 2024Review
- Effects of occupational exposure to metal fume PMInternational archives of occupational and environmental health · 2024Article
- Relationship between urinary biomarkers of early kidney damage and exposure to inorganic toxins in a pediatric population of Apizaco, Tlaxcala, Mexico.Journal of nephrology · 2023Article
- Environmental metal exposures and kidney function of Guatemalan sugarcane workers.Journal of exposure science & environmental epidemiology · 2022Article
- Assessment of biomarkers of early kidney damage and exposure to pollutants in artisanal mercury mining workers from Mexico.Environmental science and pollution research international · 2022Article
- Where do you live and what do you do? Two questions that might impact your kidney health.Frontiers in nephrology · 2022Review
- The Physiological Effects of Air Pollution: Particulate Matter, Physiology and Disease.Frontiers in public health · 2022Review
- Nephrotoxic Biomarkers with Specific Indications for Metallic Pollutants: Implications for Environmental Health.Biomarker insights · 2022Review
- A Pilot Study to Assess Inhalation Exposures among Sugarcane Workers in Guatemala: Implications for Chronic Kidney Disease of Unknown Origin.International journal of environmental research and public health · 2020Article
- Alterations by Air Pollution in Inflammation and Metals in Pleural Effusion of Pneumonia Patients.International journal of environmental research and public health · 2019Article
- Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1.Environmental research · 2016Article
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Metals cause nephrotoxicity with acute and/or chronic exposure; however, few epidemiological studies have examined impacts of exposure to metal fumes on renal injury in welding workers. In total, 66 welding workers and 12 office workers were recruited from a shipyard located in southern Taiwan. Urine samples from each subject were collected at the beginning (baseline) and end of the work week (1-week exposure). Personal exposure to PM2.5 was measured. The 8-h mean PM2.5 was 50.3 μg/m(3) for welding workers and 27.4 μg/m(3) for office workers. iTRAQs coupled with LC-MS/MS were used to discover the pathways in response to welding PM2.5 in the urine, suggesting that extracellular matrix (ECM)-receptor interactions are a critical mechanism. ECM-receptor interaction-related biomarkers for renal injury, kidney injury molecule (KIM)-1 and neutrophil gelatinase-associated lipocalin (NGAL), were significantly elevated in welding workers post-exposure, as well as were urinary Al, Cr, Mn, Fe, Co, and Ni levels. NGAL was more significantly associated with Al (r = 0.737, p < 0.001), Cr (r = 0.705, p < 0.001), Fe (r = 0.709, p < 0.001), and Ni (r = 0.657, p < 0.001) than was KIM-1, suggesting that NGAL may be a urinary biomarker for welding PM2.5 exposure. Nephrotoxicity (e.g., renal tubular injury) may be an emerging concern in occupational health.
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