ArticleEnvironmental research2016
Genetic polymorphisms are associated with hair, blood, and urine mercury levels in the American Dental Association (ADA) study participants.
Article in Environmental research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Influence of theInternational journal of environmental research and public health · 2026Article
- Relationship between susceptibility to neurodegenerative diseases and genetic factors in populations exposed to mercury in Medellín, ColombiaBiomedica : revista del Instituto Nacional de Salud · 2026Article
- Genetic Modulation of Mercury Exposure on Perinatal and Birth Outcomes: A Systematic Review and Meta-Analysis of Gene-Environment Interactions.Journal of xenobiotics · 2026Review
- TheToxics · 2024Article
- Single-Nucleotide Polymorphisms Associated with Mercury Levels and Neurological Symptoms: An Overview.Toxics · 2024Review
- Revisiting Genetic Influence on Mercury Exposure and Intoxication in Humans: A Scoping Review.Toxics · 2023Article
- Chronic Mercury Exposure andToxics · 2023Article
- Associations of Metabolic Genes (International journal of environmental research and public health · 2021Article
- Mercury level in biological samples of dentists in Iran: a systematic review and meta-analysis.Journal of environmental health science & engineering · 2020Review
- Rethinking the Dental Amalgam Dilemma: An Integrated Toxicological Approach.International journal of environmental research and public health · 2019Review
- Non-Essential Trace Elements Dietary Exposure in French Polynesia: Intake Assessment, Nail Bio Monitoring and Thyroid Cancer RiskAsian Pacific journal of cancer prevention : APJCP · 2019Article
- Maternal polymorphisms in glutathione-related genes are associated with maternal mercury concentrations and early child neurodevelopment in a population with a fish-rich diet.Environment international · 2018Article
- Modulators of mercury risk to wildlife and humans in the context of rapid global change.Ambio · 2018Article
- Calls to Florida Poison Control Centers about mercury: Trends over 2003-2013.Environmental research · 2017Article
- Genetic Aspects of Susceptibility to Mercury Toxicity: An Overview.International journal of environmental research and public health · 2017Review
- Biomarkers of mercury toxicity: Past, present, and future trends.Journal of toxicology and environmental health. Part B, Critical reviews · 2017Review
- Impaired pathways of detoxification and risk of Alzheimer's disease: Differential gene expression studies via gene set expression analysis.Journal of Alzheimer's disease reportsArticle
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND/
aimsMercury (Hg) is a potent toxicant of concern to the general public. Recent studies suggest that several genes that mediate Hg metabolism are polymorphic. We hypothesize that single nucleotide polymorphisms (SNPs) in such genes may underline inter-individual differences in exposure biomarker concentrations.
methodsDental professionals were recruited during the American Dental Association (ADA) 2012 Annual Meeting. Samples of hair, blood, and urine were collected for quantifying Hg levels and genotyping (88 SNPs in classes relevant to Hg toxicokinetics including glutathione metabolism, selenoproteins, metallothioneins, and xenobiotic transporters). Questionnaires were administrated to obtain information on demographics and sources of Hg exposure (e.g., fish consumption and use of dental amalgam). Here, we report results for 380 participants with complete genotype and Hg biomarker datasets. ANOVA and linear regressions were used for statistical analysis.
resultsMean (geometric) Hg levels in hair (hHg), blood (bHg), urine (uHg), and the average estimated Hg intake from fish were 0.62µg/g, 3.75µg/L, 1.32µg/L, and 0.12µg/kg body weight/day, respectively. Out of 88 SNPs successfully genotyped, Hg biomarker levels differed by genotype for 25 SNPs, one of which remained significant following Bonferroni correction in ANOVA. When the associations between sources of Hg exposure and SNPs were analyzed with respect to Hg biomarker concentrations, 38 SNPs had significant main effects and/or gene-Hg exposure source interactions. Twenty-five, 23, and four SNPs showed significant main effects and/or interactions for hHg, bHg, and uHg levels, respectively (p<0.05), and six SNPs (in GCLC, MT1M, MT4, ATP7B, and BDNF) remained significant following Bonferroni correction.
conclusionThe findings suggest that polymorphisms in environmentally-responsive genes can influence Hg biomarker levels. Hence, consideration of such gene-environment factors may improve the ability to assess the health risks of Hg more precisely.
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