ArticleClinical ophthalmology (Auckland, N.Z.)2015
Outcome of therapeutic penetrating keratoplasty in a tertiary eye care center in Nepal.
Article in Clinical ophthalmology (Auckland, N.Z.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 46 citations in OpenAlex.
- Predictors of Corneal Perforation or Need for Therapeutic Keratoplasty in Severe Fungal Keratitis: A Secondary Analysis of the Mycotic Ulcer Treatment Trial II.JAMA ophthalmology · 2017Trial
- Therapeutic penetrating keratoplasty for recalcitrant microbial keratitis: An update.World journal of transplantation · 2026Review
- Current Challenges and Long-Term Outcomes in Corneal Transplantation in Infectious Keratitis-A Systematic Review.Journal of clinical medicine · 2026Review
- Outcomes of Therapeutic and Tectonic Penetrating Keratoplasty for Advanced Corneal Disease.Clinical ophthalmology (Auckland, N.Z.) · 2026Article
- Optimal infiltration depth threshold for low-temperature plasma ablation in fungal keratitis.Journal of ophthalmic inflammation and infection · 2025Article
- A novel technique of penetrating keratoplasty to prevent intraocular contents extrusion for infectious keratitis.BMC ophthalmology · 2023Article
- Incidence and risk factors for glaucoma development and progression after corneal transplantation.Eye (London, England) · 2023Article
- Nonsurgical Management of Severe Viral Keratitis with Hypopyon and Retrocorneal Plaques: A Case Series.Ophthalmology and therapy · 2023Article
- Management of Filamentous Fungal Keratitis: A Pragmatic Approach.Journal of fungi (Basel, Switzerland) · 2022Review
- Combined Photoactivated Chromophore for Infectious Keratitis-Corneal Collagen Cross-Linking (PACK-CXL) and Therapeutic Penetrating Keratoplasty for Resistant Bacterial Keratitis.Clinical ophthalmology (Auckland, N.Z.) · 2022Article
- Preparation of a Nanobody Specific to Dectin 1 and Its Anti-inflammatory Effects on Fungal Keratitis.International journal of nanomedicine · 2022Article
- Changing trend in the morphology of cataracts at a tertiary eye care centre in South India due to COVID-19-pandemic related national lockdown.Indian journal of ophthalmology · 2021Article
- Impact of COVID-19 related national lockdown on care of corneal transplantation patients at a tertiary eye care centre in India.Indian journal of ophthalmology · 2021Article
- Endothelial cell loss rate after penetrating keratoplasty: optical versus therapeutic grafts.Medical hypothesis, discovery & innovation ophthalmology journal · 2021Article
- Long-term outcomes of therapeutic penetrating keratoplasty for microbial keratitis in a tertiary care center in Turkey.International ophthalmology · 2020Article
- Therapeutic penetrating keratoplasty for acanthamoeba keratitis: a review of cases, complications and predictive factors.International ophthalmology · 2019Article
- Article
- Clinical outcome after air-assisted manual deep anterior lamellar keratoplasty for fungal keratitis poorly responsive to medical treatment.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Outcomes of therapeutic keratoplasty for severe infectious keratitis in Chongqing, a 16-year experience.Infection and drug resistance · 2019Article
- Outcome of therapeutic penetrating keratoplasty in advanced infectious keratitis.Journal of current ophthalmology · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCorneal ulcer is an important cause of blindness in developing countries. Therapeutic keratoplasty for infective keratitis is a frequently performed surgery in these countries.
objectiveTo find out the outcome of therapeutic keratoplasty for infective keratitis.
methodsRecords of 5 years were reviewed of patients who underwent therapeutic keratoplasty from 2006 to 2010. Data collected included demographic parameters, indications for surgery, microbiology of the ulcers, type of surgery performed, and donor tissue details. In the follow-up period, ocular status was evaluated in terms of eradication of disease, anatomic success, graft clarity, visual acuity, and development of glaucoma and cataract.
resultsIn all, 180 eyes of 180 patients were enrolled in the study; 59.4% of the patients were male. Average age was 44.4±16.7 years. Overall, 71% of infective keratitis was perforated. A total of 101 (56%) eyes were positive for organisms of which 49 showed pure fungus and 49 showed pure bacteria. The commonest fungus and bacteria isolated were Aspergillus and Streptococcus, respectively. Average follow-up period was 29±23 months. Overall cure rate of infection was 88.8%, anatomical success rate was 89.5%, and graft clarity was 37.2%. Overall, 43.4% had secondary glaucoma. In the postoperative course, 65.8% of phakic eyes had developed cataract. In all, 38.6% of graft had endothelial failure and 24% of the graft failed due to late infective keratitis. Overall functional success with a visual acuity above 6/60 was 25.4%. Bacterial keratitis had a significantly higher cure rate, anatomical success, and graft clarity compared to fungal keratitis.
conclusionTherapeutic keratoplasty is an important procedure to save the eye and preserve vision in severe infective keratitis. There is a high incidence of postoperative glaucoma, cataract, and graft failure in such a surgery. Bacterial keratitis has a better outcome than fungal keratitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.