ArticleNature chemistry2016
Efficient, non-toxic anion transport by synthetic carriers in cells and epithelia.
Article in Nature chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed, 173 citations in OpenAlex.
- Topological Doping of Charged Bottlebrush Polymers for Efficient Artificial Ion Channels.Polymer science & technology (Washington, D.C.) · 2026Article
- Chlorination-Enhanced HChemistry, an Asian journal · 2026Article
- Medical and Nonmedical Applications of Synthetic Transmembrane Anion Transporters.Chemical reviews · 2025Review
- Rapid Water Permeation by Aramid Foldamer Nanochannels With Hydrophobic Interiors.Angewandte Chemie (International ed. in English) · 2025Article
- In vivo dynamic tracking of cerebral chloride regulation using molecularly tailored liquid/liquid interfacial ultramicro iontronics.Science advances · 2024Article
- Oriented triplex DNA as a synthetic receptor for transmembrane signal transduction.Nature communications · 2024Article
- Molecular Machines For The Control Of Transmembrane Transport.Journal of the American Chemical Society · 2023Review
- Stimulus-Controlled Anion Binding and Transport by Synthetic Receptors.Chemical reviews · 2023Review
- Article
- Halogen bonding relay and mobile anion transporters with kinetically controlled chloride selectivity.Chemical science · 2023Article
- Transmembrane Transport of Bicarbonate by Anion Receptors.ChemPlusChem · 2022Review
- A water-soluble membrane transporter for biologically relevant cations.RSC advances · 2022Article
- Measuring anion binding at biomembrane interfaces.Nature communications · 2022Article
- Calix[6]arenes with halogen bond donor groups as selective and efficient anion transporters.Chemical communications (Cambridge, England) · 2022Article
- Ion Channels and Transporters as Therapeutic Agents: From Biomolecules to Supramolecular Medicinal Chemistry.Biomedicines · 2022Review
- Recent Advances in Bioactive Artificial Ionophores.Chembiochem : a European journal of chemical biology · 2021Review
- Anion binding properties of a hollow PdL-cage.Chemical communications (Cambridge, England) · 2021Article
- New Therapies to Correct the Cystic Fibrosis Basic Defect.International journal of molecular sciences · 2021Review
- Near quantitative synthesis of urea macrocycles enabled by bulky N-substituent.Nature communications · 2021Article
- Development of effective potassium acetate extractant.RSC advances · 2021Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Transmembrane anion transporters (anionophores) have potential for new modes of biological activity, including therapeutic applications. In particular they might replace the activity of defective anion channels in conditions such as cystic fibrosis. However, data on the biological effects of anionophores are scarce, and it remains uncertain whether such molecules are fundamentally toxic. Here, we report a biological study of an extensive series of powerful anion carriers. Fifteen anionophores were assayed in single cells by monitoring anion transport in real time through fluorescence emission from halide-sensitive yellow fluorescent protein. A bis-(p-nitrophenyl)ureidodecalin shows especially promising activity, including deliverability, potency and persistence. Electrophysiological tests show strong effects in epithelia, close to those of natural anion channels. Toxicity assays yield negative results in three cell lines, suggesting that promotion of anion transport may not be deleterious to cells. We therefore conclude that synthetic anion carriers are realistic candidates for further investigation as treatments for cystic fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.