ReviewBBA clinical2015
Genetics of ischaemic stroke in young adults.
Review in BBA clinical, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Single Nucleotide Polymorphisms in Stroke: Evidence Across Susceptibility, Prognosis, and Recurrence; A Systematic Review.Journal of molecular neuroscience : MN · 2026Pooled it
- Ischaemic stroke in young adults: an overview of the classification, risk factors, aetiologies and outcomes.Singapore medical journal · 2026Review
- Article
- Identification of Monogenic Causes of Arterial Ischemic Stroke in Children with Arteriopathies by Next-Generation Sequencing.International journal of molecular sciences · 2025Article
- Clinical Approach to Genetic Cerebral Arteriopathy in the Adult Patient With Ischemic Stroke.Neurology. Genetics · 2024Review
- Review
- The NLRP3 inflammasome in ischemic stroke.Frontiers in stroke · 2024Review
- An Updated Review of Mitochondrial Transplantation as a Potential Therapeutic Strategy Against Cerebral Ischemia and Cerebral Ischemia/Reperfusion Injury.Molecular neurobiology · 2023Review
- Apolipoprotein E Gene Polymorphism Effects on Lipid Metabolism and Risk of Cerebral Infarction in Northwest Han Chinese Population.Pharmacogenomics and personalized medicine · 2023Article
- Case of cerebral venous thrombosis on a patient with background of nephrotic syndrome.BMJ case reports · 2022Article
- Impact of Clinical and Genomic Factors on COVID-19 Disease Severity.AMIA ... Annual Symposium proceedings. AMIA Symposium · 2021Article
- Molecular Biomarkers Associated with Early-Onset Symptomatic Intracranial Atherosclerosis.Clinical interventions in aging · 2021Article
- Review
- Investigating diagnostic sequencing techniques for CADASIL diagnosis.Human genomics · 2020Article
- Association between Green Tea Consumption and Risk of Stroke in Middle-Aged and Older Korean Men: The Health Examinees (HEXA) Study.Preventive nutrition and food science · 2019Article
- Risks associated with the stroke predisposition at young age: facts and hypotheses in light of individualized predictive and preventive approach.The EPMA journal · 2019Review
- Roles of blood-brain barrier integrins and extracellular matrix in stroke.American journal of physiology. Cell physiology · 2019Review
- Lnc-EPB41-Protein Interactions Associated with Congenital Pouch Colon.Biomolecules · 2018Article
- Molecular genetic studies in Saudi population; identified variants from GWAS and meta-analysis in stroke.Saudi journal of biological sciences · 2018Article
- Galectin-3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort.European journal of neurology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStroke may be a clinical expression of several inherited disorders in humans. Recognition of the underlined genetic disorders causing stroke is important for a correct diagnosis, for genetic counselling and, even if rarely, for a correct therapeutic management. Moreover, the genetics of complex diseases such the stroke, in which multiple genes interact with environmental risk factors to increase risk, has been revolutionized by the Genome-Wide Association Study (GWAS) approach. SCOPE OF REVIEW: Here we review the single-gene causes of ischemic stroke, bringing the reader from the candidate gene method toward the exciting new horizons of genetic technology. MAJOR
conclusionsThe aetiological diagnosis of ischemic stroke in young adults is more complex than in the elderly. The identification of a genetic cause is important to provide appropriate counseling and to start a correct therapy, when available. The advent of GWAS technology, such as for other complex pathological conditions, has contributed enormously to the understanding of many of these genetic bases. For success large, well phenotyped case cohorts are required, and international collaborations are essential. GENERAL SIGNIFICANCE: This review focuses on the main causes of genetically-based ischemic stroke in young adults, often classified as indeterminate, investigating also the recent findings of the GWAS, in order to improve diagnostic and therapeutic management.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.