ArticleAmerican journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics2015
Bone and cartilage changes in rabbit mandibular condyles after 1 injection of botulinum toxin.
Article in American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 38 citations in OpenAlex.
- Botulinum toxin type A applications for masticatory myofascial pain and trigeminal neuralgia: what is the evidence regarding adverse effects?Clinical oral investigations · 2019Pooled it
- Is there enough evidence to use botulinum toxin injections for bruxism management? A systematic literature review.Clinical oral investigations · 2017Pooled it
- Influence of botulinum toxin A in pain perception and condyle-fossa relationship after the management of temporomandibular dysfunction: a randomized controlled clinical trial.Oral and maxillofacial surgery · 2024Trial
- Efficacy and Safety of Botulinum Toxin Type A on Persistent Myofascial Pain: A Randomized Clinical Trial.Toxins · 2020Trial
- Observational
- Evaluation of morphological variations of mandibular bone in adult bruxers using CBCT: A cross-sectional study.PloS one · 2026Article
- Article
- Effect of multiple injections of botulinum toxin into painful masticatory muscles on bone density in the temporomandibular complex.Journal of oral rehabilitation · 2020Article
- Effect of bisphosphonate on temporomandibular joint in osteopenia-induced rats by botulinum toxin A injection on masticatory muscle: a preliminary study.Maxillofacial plastic and reconstructive surgery · 2019Article
- The effects on the mandibular condyle of Botox injection into the masseter are not transient.American journal of orthodontics and dentofacial orthopedics : official publication of the American Association of Orthodontists, its constituent societies, and the American Board of Orthodontics · 2019Article
- Review
- Review
- Repeated injections of botulinum toxin into the masseter muscle induce bony changes in human adults: A longitudinal study.Korean journal of orthodontics · 2017Article
- Cellular and Matrix Response of the Mandibular Condylar Cartilage to Botulinum Toxin.PloS one · 2016Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
introductionTemporary paralysis of the masseter muscle caused by botulinum toxin is a common treatment for temporomandibular disorders, bruxism, and muscle hypertrophy. Loss of masseter force is associated with decreased mandibular mineral density. Our objectives were (1) to establish whether bone loss at the mandibular condyle is regionally specific and (2) to ascertain whether the treatment affects the condylar cartilage.
methodsYoung adult female rabbits received a unilateral masseter injection of botulinum neurotoxin serotype A (BoNT/A, n = 31), saline solution (n = 19), or no injection (n = 3) and were also injected with bromodeoxyuridine (BrdU), a replication marker. The rabbits were killed at 4 or 12 weeks after treatment. The condyles were processed for paraffin histology. Cortical thickness, cartilage thickness, and trabecular bone areal density were measured, and replicating cells were counted after BrdU reaction.
resultsThe BoNT/A rabbits exhibited a high frequency of defects in the condylar bone surface, occurring equally on the injected and uninjected sides. Bone loss was seen only on the side of the BoNT/A injection. Cortical as well as trabecular bone was severely affected. The midcondylar region lost the most bone. Recovery at 12 weeks was insignificant. Condylar cartilage thickness showed no treatment effect but did increase with time. The numbers of proliferating cells were similar in the treatment groups, but the BoNT/A animals showed more side asymmetry associated with the condylar defects.
conclusionsBone loss may be a risk factor for the use of botulinum toxin in jaw muscles.
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