Evidence map›Paper›PMID 26672513›Full record

ArticleWorld journal of gastroenterology2015

Association between hepatocellular carcinoma and tumor necrosis factor alpha polymorphisms in South Korea.

Suk Pyo Shin, Nam Keun Kim, Ju Hwan Kim, Ju Ho Lee, Jung Oh Kim, Sung Hwan Cho, Hana Park, Mi Na Kim, Kyu Sung Rim, Seong Gyu Hwang

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 4 pooled it
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Tumor Necrosis Factor-Disease markers · 2016
    Pooled it
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Suk Pyo ShinSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Nam Keun KimSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Ju Hwan KimSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Ju Ho LeeSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Jung Oh KimSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Sung Hwan ChoSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Hana ParkSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Mi Na KimSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Kyu Sung RimSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
Seong Gyu HwangSuk Pyo Shin, Ju Hwan Kim, Ju Ho Lee, Hana Park, Kyu Sung Rim, Seong Gyu Hwang, Department of Internal Medicine, CHA Bundang Medical Center, CHA University, Seongnam 463-712, South Korea.
CHA University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate associations between the tumor necrosis factor alpha (TNF-α) -1031 T>C, -863 C>A, -857 C>T, -308 G>A, and -238 G>A polymorphisms and HCC in Korea.

methodsHepatocellular carcinoma (HCC) cases were diagnosed at CHA Bundang Medical Center from June 1996 to August 2008. The association between TNF-α polymorphisms and HCC was analyzed in 157 HCC patients and 201 controls using a polymerase chain reaction-restriction fragment length polymorphism assay. We investigated five TNF-α polymorphisms, which are TNF-α -1031 T>C, -863 C>A, -857 C>T, -308 G>A, and -238 G>A. The TNF-α genotype frequencies, genotype combinations and haplotypes were analyzed to disclose the association with HCC.

resultsNone of the TNF-α polymorphisms was significantly associated with HCC. However, nine genotype combinations had associations with increased likelihood of HCC. Among them, TNF-α -1031/-857/-238 TT/CC/GA (AOR = 18.849, 95%CI: 2.203-161.246, P = 0.007), TNF-α -1031/-308/-238 TT/GG/GA (AOR = 26.956, 95%CI: 3.071-236.584, P = 0.003), and TNF-α -1031/-238 TT/GA (AOR = 21.576, 95%CI: 2.581-180.394, P = 0.005) showed marked association with HCC. There were five haplotypes of TNF-α polymorphisms which were significantly associated with HCC. They are TNF-α -1031/-863/-857/-308/-238 T-C-C-G-A (OR = 25.824, 95%CI: 1.491-447.223, P = 0.0005), TNF-α -1031/-857/-308/-238 T-C-G-A (OR = 12.059, 95%CI: 2.747-52.950, P < 0.0001), TNF-α -1031/-857/-238 T-C-A (OR = 10.696, 95%CI: 2.428-47.110, P = 0.0001), TNF-α -1031/-308/-238 T-G-A (OR = 7.556, 95%CI: 2.173-26.280, P = 0.0002) and TNF-α -1031/-238 T-A (OR = 10.865, 95%CI: 2.473-47.740, P = 0.0001). Moreover, HCC Okuda stage III cases with the TNF-α -1031 CC genotype had better survival than those with the TT genotype (AOR = 5.795, 95%CI: 1.145-29.323).

conclusionAlthough no single TNF-α polymorphism is associated with HCC in this study, some TNF-α genotype combinations and haplotypes are associated with HCC. In addition, HCC Okuda stage III cases with the TNF-α -1031 TT genotype may have a better prognosis than those with the CC genotype.

Indexed as

Polymorphism, GeneticAdultAgedAsian PeopleCarcinoma, HepatocellularCase-Control StudiesChi-Square DistributionFemaleGene FrequencyGenetic Association StudiesGenetic Predisposition to DiseaseHaplotypesHumansKaplan-Meier EstimateLiver NeoplasmsLogistic ModelsTumor Necrosis Factor-alphaCarcinomaHepatocellularPolymorphismSingle nucleotideTumor necrosis factor-alpha

Identifiers

PMID26672513
PMCPMC4674724
OpenAlexW2411692350

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.