Evidence map›Paper›PMID 26672078›Full record

ArticleJournal of the American Heart Association2015

Risk Factor Stratification for Intracranial Stenosis in Taiwanese Patients With Cervicocerebral Stenosis.

Yueh-Feng Sung, Jiunn-Tay Lee, Chia-Lin Tsai, Chun-Chieh Lin, Yaw-Don Hsu, Jiann-Chyun Lin, Chi-Ming Chu, Giia-Sheun Peng

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04162587 (Association Between Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke Patients), which is not on this map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04162587 unknown statusnot on this mapstarted 2019, after this paper: background citation

Association Between Extracranial Carotid & Intracranial Arterial Stenosis in Ischemic Stroke Patients: Predictors & Outcome

TypeobservationalSponsorMansoura University HospitalRan2019 to 2020Enrolled120ConditionsIschemic Stroke, Carotid StenosisArmsCarotid duplex+/- MRA neck, brain MRA+/-CT angio on carotid and brain, MRI brain, DSA (digital subtraction angiography)
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Physical activity attenuates the association between household air pollution and health-related quality of life in Chinese rural population: the Henan Rural Cohort Study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Yueh-Feng SungGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (Y.F.S., C.L.T., G.S.P.) Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.).
Jiunn-Tay LeeDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.).
Chia-Lin TsaiGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (Y.F.S., C.L.T., G.S.P.) Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.).
Chun-Chieh LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.).
Yaw-Don HsuDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.).
Jiann-Chyun LinDepartment of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.).
Chi-Ming ChuDepartment of Epidemiology, School of Public Health, National Defense Medical Center, Taipei, Taiwan (C.M.C.).
Giia-Sheun PengGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei, Taiwan (Y.F.S., C.L.T., G.S.P.) Department of Neurology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan (Y.F.S., J.T.L., C.L.T., C.C.L., Y.D.H., J.C.L., G.S.P.) Section of Neurology, Department of Internal Medicine, Taipei Veterans General Hospital, Hsinchu Branch, Hsinchu County, Taiwan (G.S.P.).
Tri-Service General Hospital · TWNational Defense Medical Center · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIntracranial stenosis (ICS) is a major determinant of ischemic stroke in Asians. We determined the clinical significance of different risk factors and the role of ICS in Taiwanese patients with varied distributions of cervicocerebral stenosis. METHODS AND

resultsPresence of extracranial carotid stenosis (ECS, ≥70%) and ICS (>50%) was examined in 13 539 patients using ultrasonography and magnetic resonance angiography, respectively. Seven hundred thirty-three patients with non-ECS/ICS (n=372), isolated ICS (n=112), isolated ECS (n=121), or combined ECS/ICS (CEIS, n=128) were selected. Prevalence of ischemic stroke in each group was compared, and risk factors for stenosis were determined. The area under the receiver operating characteristic curve for each risk factor was calculated. Prevalence of ischemic stroke was highest in patients with CEIS (odds ratio 15.86; P<0.001), followed in decreasing order by those with isolated ICS (odds ratio 7.16; P<0.001), isolated ECS (odds ratio 1.77; P=0.011), and non-ECS/ICS. Multivariate logistic regression analysis revealed that hypertension, coronary artery disease, and smoking were risk factors for isolated ECS; hypertension, diabetes mellitus, coronary artery disease, and smoking were risk factors for isolated ICS; and diabetes mellitus, coronary artery disease, and smoking were risk factors for CEIS. Smoking, diabetes mellitus, and coronary artery disease were the greatest contributors to CEIS, isolated ICS, and isolated ECS, respectively.

conclusionsCEIS was associated with higher odds of ischemic stroke compared with isolated ICS and isolated ECS. Smoking and diabetes mellitus, major determinants of CEIS and isolated ICS, should be targeted in therapeutic strategies to reduce the risk of ischemic stroke.

Indexed as

AgedAge FactorsBrain IschemiaCarotid StenosisFemaleHumansLogistic ModelsMagnetic Resonance AngiographyMalePrevalenceRetrospective StudiesRisk FactorsROC CurveSex FactorsStrokeTaiwanatherosclerosiscarotid arteriesrisk factorsstenosisstroke

Identifiers

PMID26672078
PMCPMC4845266
OpenAlexW2196651492

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.