Evidence map›Paper›PMID 26672022›Full record

Trial reportPediatrics2016

A Comparison of Strategies for Retinopathy of Prematurity Detection.

Alex R Kemper, Lisa A Prosser, Kelly C Wade, Michael X Repka, Gui-shuang Ying, Agnieshka Baumritter, Graham E Quinn, e-ROP Study Cooperative Group

Abstract readClinical TrialComparative Study
In one paragraph

Trial report in Pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Practice Guidelines for Ocular Telehealth-Diabetic Retinopathy, Third Edition.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2020
    Article
  5. Telemedicine for Retinopathy of Prematurity.Telemedicine journal and e-health : the official journal of the American Telemedicine Association · 2020
    Review
  6. Article
  7. Article
  8. Factors associated with retinopathy of prematurity ophthalmology workload.Journal of perinatology : official journal of the California Perinatal Association · 2018
    Article
  9. Review
  10. Article
  11. Retinopathy of Prematurity: Imaging in retinopathy of prematurity: where are we, and where are we going?Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus · 2016
    Article
  12. Observational
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Alex R KemperDuke Clinical Research Institute, Durham, North Carolina; alex.kemper@duke.edu.
Lisa A ProsserChild Health Evaluation and Research Unit, Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, Michigan;
Kelly C WadeDepartment of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania;
Michael X RepkaDepartment of Ophthalmology, Johns Hopkins School of Medicine, Baltimore, Maryland;
Gui-shuang YingCenter for Preventive Ophthalmology and Biostatistics, Department of Ophthalmology, Perelman School of Medicine, Philadelphia, Pennsylvania; and.
Agnieshka BaumritterDivision of Pediatric Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.
Graham E QuinnDivision of Pediatric Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania.
e-ROP Study Cooperative Group

Funding

Scientific TransparencyP30EY001583 · NEI · UNIVERSITY OF PENNSYLVANIA · PI Qi N Cui · 1985 to 2026
$19.5M
Telemedicine Approaches to Evaluating Acute-phase ROP - eROPU10EY017014 · NEI · CHILDREN'S HOSP OF PHILADELPHIA · PI QUINN, GRAHAM E · 2010 to 2013
$13.6M
NEI NIH HHS P30 EY001583NEI NIH HHS U10 EY017014NEI NIH HHS U10EY017014
6 · The paper itself

Abstract

BACKGROUND AND

objectivesDelayed detection of type 1 retinopathy of prematurity (ROP) can lead to permanent visual impairment. Providing ROP examinations is challenging because of the limited ophthalmology workforce. This study compares digital imaging-based ROP detection strategies versus serial ROP examinations.

methodsWe conducted an individual-level microsimulation study of a hypothetical cohort of 650 infants with gestational age from 23 to 30 weeks. Infants were evaluated by using strategies based on indirect ophthalmoscopy or digital imaging beginning at 32 weeks' postmenstrual age (PMA) and continuing to discharge, transfer, or 40 weeks' PMA. ROP status and the accuracy of digital imaging were based on the e-ROP (Telemedicine Approaches to Evaluating Acute-Phase ROP) study, which enrolled high-risk infants.

resultsWithin the hypothetical NICU, the strategy of ROP examinations identified an average of 45.8 cases of type 1 ROP by discharge, transfer, or 40 weeks' PMA, and another 1.9 cases were included in the group of infants recommended to have later follow-up. Digital imaging with an ROP examination at discharge identified all 47.7 cases of type 1 ROP. On average, the ROP examination-only strategy required 1745.7 ROP examinations, whereas digital imaging with a discharge examination required 1065.5 ROP examinations and 1786.2 digital imaging sessions.

conclusionsAlthough digital imaging decreased the number of ROP examinations per infant, there was an increase in the total number of interventions (ie, ROP examinations and imaging sessions). Providing an ROP examination at the time of NICU discharge can significantly reduce the number of infants who require follow-up.

Indexed as

Diagnostic Techniques, OphthalmologicalHumansInfant, NewbornNeonatal ScreeningRetinopathy of Prematurity

Identifiers

PMID26672022
PMCPMC4702020

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.