ArticleScientific reports2015
Stochasticity and homeostasis in the E. coli replication and division cycle.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
37 citing papers in PubMed, 71 citations in OpenAlex.
- Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Live tracking of replisomes reveals nutrient-dependent regulation of replication elongation rates in Caulobacter crescentus.Current biology : CB · 2025Article
- Direct single-cell observation of a keyScience advances · 2024Article
- The Quantification of Bacterial Cell Size: Discrepancies Arise from Varied Quantification Methods.Life (Basel, Switzerland) · 2023Article
- Beyond the average: An updated framework for understanding the relationship between cell growth, DNA replication, and division in a bacterial system.PLoS genetics · 2023Article
- Robust replication initiation from coupled homeostatic mechanisms.Nature communications · 2022Article
- Scaling of biosynthesis and metabolism with cell size.Molecular biology of the cell · 2022Article
- Article
- Bacterial cell proliferation: from molecules to cells.FEMS microbiology reviews · 2021Review
- Quantitative Examination of Five Stochastic Cell-Cycle and Cell-Size Control Models forFrontiers in microbiology · 2021Article
- Article
- Deciphering Metabolic Heterogeneity by Single-Cell Analysis.Analytical chemistry · 2019Article
- Microfluidic time-lapse analysis and reevaluation of the Bacillus subtilis cell cycle.MicrobiologyOpen · 2019Article
- Mechanistic Origin of Cell-Size Control and Homeostasis in Bacteria.Current biology : CB · 2019Article
- Article
- Concurrent processes setScience advances · 2018Article
- Surface Area to Volume Ratio: A Natural Variable for Bacterial Morphogenesis.Trends in microbiology · 2018Article
- Size control in mammalian cells involves modulation of both growth rate and cell cycle duration.Nature communications · 2018Article
- A Markovian Approach towards Bacterial Size Control and Homeostasis in Anomalous Growth Processes.Scientific reports · 2018Article
- Fundamental principles in bacterial physiology-history, recent progress, and the future with focus on cell size control: a review.Reports on progress in physics. Physical Society (Great Britain) · 2018Review
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
How cells correct for stochasticity to coordinate the chromosome replication and cellular division cycle is poorly understood. We used time-lapse microscopy and fluorescently labelled SeqA to determine the timing of birth, initiation, termination, and division, as well as cell size throughout the cell cycle. We found that the time between birth and initiation (B-period) compensates for stochastic variability in birth size and growth rate. The time between termination and division (D-period) also compensates for size and growth variability, invalidating the notion that replication initiation is the principal trigger for cell division. In contrast, the time between initiation and termination (C-period) did not display such compensations. Interestingly, the C-period did show small but systematic decreases for cells that spontaneously grew faster, which suggests a coupling between metabolic fluctuations and replication. An auto-regressive theoretical framework was employed to compare different possible models of sub-period control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.