Evidence map›Paper›PMID 26671658›Full record

ReviewNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2016

Enhancing Rehabilitative Therapies with Vagus Nerve Stimulation.

Seth A Hays

2 registry-linked trialsOpen access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 60 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
4.5field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03592745 phase2completednot on this mapstarted 2018, after this paper: background citation

Evaluating the Use of Transcutaneous Vagus Nerve Stimulation (tVNS) and Robotic Training to Improve Upper Limb Motor Recovery After Stroke

TypeinterventionalSponsorNorthwell HealthRan2018 to 2021Enrolled36ConditionsStroke, Cerebrovascular Accident (CVA), HemiparesisArmsTranscutaneous Vagus Nerve Stimulation (tVNS), Sham Transcutaneous Vagus Nerve Stimulation (tVNS)
NCT07272239 narecruitingnot on this mapstarted 2025, after this paper: background citation

Combined Effects of Transcutaneous Vagus Nerve Stimulation and Modified Constraint Induced Movement Therapy on Upper Extremity Function, Cognition and Quality of Life in Individual With Chronic Stroke

TypeinterventionalSponsorRiphah International UniversityRan2025 to 2026Enrolled50ConditionsStroke, Cerebrovascular AccidentArmsTranscutaneous Vagus Nerve Stimulation, Modified Constraint Induced Movement Therapy with Routine Physical Therapy
3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 1 synthesis or guideline pooled it, 108 citations in OpenAlex.

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  20. Noninvasive Vagal Nerve Stimulation for Opioid Use Disorder.Annals of depression and anxiety · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Seth A HaysTexas Biomedical Device Center, Richardson, TX, USA. sxh129730@utdallas.edu.ORCID http://orcid.org/0000-0003-4225-241X
Texas Biomedical Research Institute · US

Funding

Vagus Nerve Stimulation Paired with Rehabilitative Training to Enhance PlasticityR01NS085167 · NINDS · UNIVERSITY OF TEXAS DALLAS · PI KILGARD, MICHAEL P, RENNAKER, ROBERT L · 2014 to 2018
$1.9M
NINDS NIH HHS R01 NS085167
6 · The paper itself

Abstract

Pathological neural activity could be treated by directing specific plasticity to renormalize circuits and restore function. Rehabilitative therapies aim to promote adaptive circuit changes after neurological disease or injury, but insufficient or maladaptive plasticity often prevents a full recovery. The development of adjunctive strategies that broadly support plasticity to facilitate the benefits of rehabilitative interventions has the potential to improve treatment of a wide range of neurological disorders. Recently, stimulation of the vagus nerve in conjunction with rehabilitation has emerged as one such potential targeted plasticity therapy. Vagus nerve stimulation (VNS) drives activation of neuromodulatory nuclei that are associated with plasticity, including the cholinergic basal forebrain and the noradrenergic locus coeruleus. Repeatedly pairing brief bursts of VNS sensory or motor events drives robust, event-specific plasticity in neural circuits. Animal models of chronic tinnitus, ischemic stroke, intracerebral hemorrhage, traumatic brain injury, and post-traumatic stress disorder benefit from delivery of VNS paired with successful trials during rehabilitative training. Moreover, mounting evidence from pilot clinical trials provides an initial indication that VNS-based targeted plasticity therapies may be effective in patients with neurological diseases and injuries. Here, I provide a discussion of the current uses and potential future applications of VNS-based targeted plasticity therapies in animal models and patients, and outline challenges for clinical implementation.

Indexed as

HumansNervous System DiseasesNeuronal PlasticityTrauma, Nervous SystemVagus Nerve StimulationNeuroplasticityRehabilitationStrokeTinnitusVagal nerve stimulationVagus nerve stimulation

Identifiers

PMID26671658
PMCPMC4824018
OpenAlexW2205637517

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.