ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
The prediction of survival of patients with gastric cancer with PD-L1 expression using contrast-enhanced ultrasonography.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 11 citations in OpenAlex.
- Application value of gastric contrast ultrasonography in gastric tumors.Insights into imaging · 2026Review
- Article
- Clinical value of oral contrast-enhanced ultrasonography in diagnosis of gastric tumors.World journal of gastrointestinal oncology · 2024Article
- Contrast-Enhanced Ultrasound Parameters and D-Dimer: New Prognostic Parameters for Diffuse Large B-Cell Lymphoma.Cancer management and research · 2022Article
- Clinicopathological and prognostic significance of programmed death ligant-1 expression in gastric cancer: a meta-analysis.Journal of gastrointestinal oncology · 2021Article
- Transcriptomic and Genomic Testing to Guide Individualized Treatment in Chemoresistant Gastric Cancer Case.Biomedicines · 2020Article
- Immunotherapeutic Strategies for Gastric Carcinoma: A Review of Preclinical and Clinical Recent Development.BioMed research international · 2017Review
- Prognostic and predictive values of PD-L1 expression in patients with digestive system cancer: a meta-analysis.OncoTargets and therapy · 2017Article
- The clinicopathological and prognostic significance of PD-L1 expression in gastric cancer: a meta-analysis of 10 studies with 1,901 patients.Scientific reports · 2016Article
- Antagonizing programmed death-1 and programmed death ligand-1 as a therapeutic approach for gastric cancer.Therapeutic advances in gastroenterology · 2016Review
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastric cancer is the one of the most common cancers around the world. The prognosis of gastric cancer remains poor, due to the biological characteristics of the primary tumor as well as the recurrence after treatment. Accumulating evidence suggests the implication of programmed death ligand-1 (PD-L1) in the pathogenesis and prognosis of cancer. This study aimed to explore the CEUS as a valuable tool to improve the assessment of the therapeutic effect of the PD-L1 blocker in the treatment of gastric cancer. A total number of 105 patients with gastric cancer were enrolled in this study from June 2008 to December 2011 in our hospital. The association of PD-L1 expression level (105 cases) and CEUS parameters (100 cases) with the prognosis of gastric cancer was examined. The results showed that PD-L1-positive staining was associated with the depth of invasion, differentiation, and poor prognosis of patients with gastric cancer. The CEUS intensity (positive) exhibited poor prognosis compared to the negative counterpart. Moreover, PD-L1 and CEUS co-positivity was significantly related to a poor prognosis. The characteristic of ultrasonography images correlated with the expression of PD-L1 (r = 0.46, P = 0.0003). Collectively, the mean intensity of contrast-enhanced ultrasonography is a useful predictor in the PD-L1 expression in gastric cancer. The ultrasonography and CEUS parameter could be considered as the predictor of response to PD-L1 blocker treatment in the clinical practice.
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