ArticlePloS one2015
A Comprehensive Study of Extramural Venous Invasion in Colorectal Cancer.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05331040 (The New Challenge of Decoding Rectal Cancer Signatures By Non-Invasive Imaging), which is not on this map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The New Challenge of Decoding Rectal Cancer Signatures By Non-Invasive Imaging: A Retrospective Radiomics Study
Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Histopathological characteristics of screen-detected colorectal cancers.Virchows Archiv : an international journal of pathology · 2026Article
- Controversies and Perspectives in the Current Management of Patients with Locally Advanced Rectal Cancer-A Systematic Review.Life (Basel, Switzerland) · 2025Review
- Role of Computed Tomography in Predicting Programmed Death Ligand-1 Positivity in Gastric Adenocarcinoma.Journal of multidisciplinary healthcare · 2025Article
- Article
- Risk Factors for Distant Metastasis in T3 T4 Rectal Cancer.Clinical Medicine Insights. Oncology · 2024Article
- Value of texture analysis based on dynamic contrast-enhanced magnetic resonance imaging in preoperative assessment of extramural venous invasion in rectal cancer.Insights into imaging · 2022Article
- Article
- The value of tumor deposits in evaluating colorectal cancer survival and metastasis: a population-based retrospective cohort study.World journal of surgical oncology · 2022Article
- Multiparameter MRI-based radiomics for preoperative prediction of extramural venous invasion in rectal cancer.European radiology · 2022Article
- Perioperative and oncologic outcomes in young and octogenarian patients with colorectal cancer: a comparison at the extremes.Langenbeck's archives of surgery · 2021Article
- MRI Evaluation of Extramural Venous Invasion (EMVI) with Rectal Carcinoma Using High Resolution T2 and Combination of High Resolution T2 and Contrast Enhanced T1 Weighted Imaging.Acta informatica medica : AIM : journal of the Society for Medical Informatics of Bosnia & Herzegovina : casopis Drustva za medicinsku informatiku BiH · 2021Article
- Machine Learning-Based Radiomics Nomogram for Detecting Extramural Venous Invasion in Rectal Cancer.Frontiers in oncology · 2021Article
- Diagnosis and prognostic significance of extramural venous invasion in neuroendocrine tumors of the small intestine.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2020Article
- Magnetic resonance imaging performed before and after preoperative chemoradiotherapy in rectal cancer: predictive factors of recurrence and prognostic significance of MR-detected extramural venous invasion.Abdominal radiology (New York) · 2020Article
- Preoperative Prediction of Extramural Venous Invasion in Rectal Cancer: Comparison of the Diagnostic Efficacy of Radiomics Models and Quantitative Dynamic Contrast-Enhanced Magnetic Resonance Imaging.Frontiers in oncology · 2020Article
- Prognostic value of MRI in assessing extramural venous invasion in rectal cancer: multi-readers' diagnostic performance.European radiology · 2019Article
- ASO Author Reflections: Diagnostic Significance of Extramural Venous Invasion in Patients with Locally Advanced Esophageal Cancer.Annals of surgical oncology · 2018Article
- Prevalence and Prognostic Significance of Extramural Venous Invasion in Patients with Locally Advanced Esophageal Cancer.Annals of surgical oncology · 2018Article
- Article
- Correlations of ICAM-1 gene polymorphisms with susceptibility and multidrug resistance in colorectal cancer in a Chinese population.Medicine · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer is a common malignancy and a leading cause of cancer related death. Cancer staging following resection is key to determining any adjuvant therapy in those patients with high risk disease. In colorectal cancer, tumour stage and lymph node stage are the main pathological factors which have been considered to influence outcome. Increasing emphasis is now being placed on other factors, especially the presence of extramural venous invasion (EMVI). It is important to understand the relationship of EMVI with other pathological factors and to confirm that in an individual centre that EMVI is being detected at an appropriate rate and is of prognostic significance. This comprehensive study assesses the reporting and prognostic significance of EMVI in a single centre, using prospectively collected data from histopathology reports of a cohort of 2405 patients who underwent surgery for colorectal cancer over a nine year period. Overall, EMVI was reported in 27.9% of colorectal cancer excision specimens. In tumours (n = 1928) that had not received neoadjuvant therapy, the presence of EMVI varied significantly depending on tumour site (χ2 = 12.03, p<0.005), tumour stage (χ2 = 268.188, p<0.001), lymph node stage (χ2 = 294.368, p<0.001) and Dukes' stage (χ2 = 253.753, p<0.001). Multivariate analysis confirmed EMVI as a significant independent prognostic indicator (p<0.001). In conclusion, the presence of EMVI as an independent prognostic indicator is shown and is related to other pathological and prognostic factors. This study emphasises the requirement for the accurate identification of EMVI in colorectal cancer excision specimens and also understanding the relationship of EMVI with other prognostic factors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.