ArticleScientific reports2015
Dysfunctional vestibular system causes a blood pressure drop in astronauts returning from space.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Cardiovascular Adaptations of Space Travel: A Systematic Review.Cardiology · 2023Pooled it
- Hemodynamic orthostatic dizziness/vertigo: Diagnostic criteria.Journal of vestibular research : equilibrium & orientationGuideline
- Long-term exposure to microgravity impairs vestibulo-cardiovascular reflex.Scientific reports · 2016Trial
- Neural correlates of vestibular adaptation in cosmonauts after long duration spaceflight.NPJ microgravity · 2025Article
- Update on Clinical Physiology and Pathomechanisms for Vestibulo-Autonomic Interplay.Cerebellum (London, England) · 2025Review
- Increased Homer Activity and NMJ Localization in the Vestibular LesionInternational journal of molecular sciences · 2024Article
- Long-term space missions' effects on the human organism: what we do know and what requires further research.Frontiers in physiology · 2024Review
- Cognition in zero gravity: Effects of non-terrestrial gravity on human behaviour.Quarterly journal of experimental psychology (2006) · 2023Article
- Cardiovascular autonomic nervous system responses and orthostatic intolerance in astronauts and their relevance in daily medicine.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Can Dyssynergia of Vestibulosympathetic and Baroreflexes Cause Vestibular Syncope? The Hypothesis Based on the Velocity-Storage Function.Cerebellum (London, England) · 2022Article
- Future research directions to identify risks and mitigation strategies for neurostructural, ocular, and behavioral changes induced by human spaceflight: A NASA-ESA expert group consensus report.Frontiers in neural circuits · 2022Article
- The Role of Different Afferent Systems in the Modulation of the Otolith-Ocular Reflex After Long-Term Space Flights.Frontiers in physiology · 2022Article
- Vestibular Illusions and Alterations in Aerospace Environment.Turkish archives of otorhinolaryngology · 2021Review
- Temporary Unilateral Caloric Vestibular Stimulation Affects Balance and Gait Control During Walking in Healthy Young Adults.The journal of international advanced otology · 2021Article
- The Role of Long-Term Head-Down Bed Rest in Understanding Inter-Individual Variation in Response to the Spaceflight Environment: A Perspective Review.Frontiers in physiology · 2021Article
- Understanding vestibular-related physiological functions could provide clues on adapting to a new gravitational environment.The journal of physiological sciences : JPS · 2020Review
- Impacts of Microgravity Analogs to Spaceflight on Cerebral Autoregulation.Frontiers in physiology · 2020Review
- Effects of centrifugation and whole-body vibrations on blood-brain barrier permeability in mice.NPJ microgravity · 2020Article
- Hypergravity-induced plastic alteration of the vestibulo-sympathetic reflex involves decrease in responsiveness of CAMK2-expressing neurons in the vestibular nuclear complex.The journal of physiological sciences : JPS · 2019Article
- Association between Syncope and Tumarkin Attacks in Ménière's Disease.The journal of international advanced otology · 2019Article
Corrections and comments
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Authors and funding
11 authors at 8 institutions in 5 countries.
Funding
Abstract
It is a challenge for the human body to maintain stable blood pressure while standing. The body's failure to do so can lead to dizziness or even fainting. For decades it has been postulated that the vestibular organ can prevent a drop in pressure during a position change--supposedly mediated by reflexes to the cardiovascular system. We show--for the first time--a significant correlation between decreased functionality of the vestibular otolith system and a decrease in the mean arterial pressure when a person stands up. Until now, no experiments on Earth could selectively suppress both otolith systems; astronauts returning from space are a unique group of subjects in this regard. Their otolith systems are being temporarily disturbed and at the same time they often suffer from blood pressure instability. In our study, we observed the functioning of both the otolith and the cardiovascular system of the astronauts before and after spaceflight. Our finding indicates that an intact otolith system plays an important role in preventing blood pressure instability during orthostatic challenges. Our finding not only has important implications for human space exploration; they may also improve the treatment of unstable blood pressure here on Earth.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.