Evidence map›Paper›PMID 26670924›Full record

ArticleThe Journal of physiology2016

Angiopoietin-like 4 promotes angiogenesis in the tendon and is increased in cyclically loaded tendon fibroblasts.

Rouhollah Mousavizadeh, Alex Scott, Alex Lu, Gholamreza S Ardekani, Hayedeh Behzad, Kirsten Lundgreen, Mazyar Ghaffari, Robert G McCormack, Vincent Duronio

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 25 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Rouhollah MousavizadehJack Bell Research Centre, Department of Medicine, University of British Columbia, Vancouver, Canada.
Alex ScottDepartment of Physical Therapy, University of British Columbia, Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, Canada.
Alex LuDepartment of Physical Therapy, University of British Columbia, Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, Canada.
Gholamreza S ArdekaniJack Bell Research Centre, Department of Medicine, University of British Columbia, Vancouver, Canada.
Hayedeh BehzadDepartment of Physical Therapy, University of British Columbia, Centre for Hip Health and Mobility, Vancouver Coastal Health Research Institute, Vancouver, Canada.
Kirsten LundgreenDepartment of Orthopaedic Surgery, Lovisenberg Diaconal Hospital, Oslo, Norway.
Mazyar GhaffariJack Bell Research Centre, Department of Medicine, University of British Columbia, Vancouver, Canada.
Robert G McCormackDepartment of Orthopedic Surgery, University of British Columbia, Vancouver, Canada.
Vincent DuronioJack Bell Research Centre, Department of Medicine, University of British Columbia, Vancouver, Canada.
University of British Columbia · CABell (Canada) · CALovisenberg Diakonale Høgskole · NOVancouver Coastal Health · CAVancouver Coastal Health Research Institute · CA

Funding

CIHR
6 · The paper itself

Abstract

key pointsAngiopoietin-like 4 (ANGPTL4) modulates tendon neovascularization. Cyclic loading stimulates the activity of transforming growth factor-β and hypoxia-inducible factor 1α and thereby increases the expression and release of ANGPTL4 from human tendon cells. Targeting ANGPTL4 and its regulatory pathways is a potential avenue for regulating tendon vascularization to improve tendon healing or adaptation. ABSTRACT: The mechanisms that regulate angiogenic activity in injured or mechanically loaded tendons are poorly understood. The present study examined the potential role of angiopoietin-like 4 (ANGPTL4) in the angiogenic response of tendons subjected to repetitive mechanical loading or injury. Cyclic stretching of human tendon fibroblasts stimulated the expression and release of ANGPTL4 protein via transforming growth factor-β (TGF-β) and hypoxia-inducible factor 1α (HIF-1α) signalling, and the released ANGPTL4 was pro-angiogenic. Angiogenic activity was increased following ANGPTL4 injection into mouse patellar tendons, whereas the patellar tendons of ANGPTL4 knockout mice displayed reduced angiogenesis following injury. In human rotator cuff tendons, the expression of ANGPTL4 was correlated with the density of tendon endothelial cells. To our knowledge, this is the first study characterizing a role of ANGPTL4 in the tendon. ANGPTL4 may assist in the regulation of vascularity in the injured or mechanically loaded tendon. TGF-β and HIF-1α comprise two signalling pathways that modulate the expression of ANGPTL4 by mechanically stimulated tendon fibroblasts and, in the future, these could be manipulated to influence tendon healing or adaptation.

Indexed as

Amino Acids, DicarboxylicAngiopoietin-Like Protein 4AngiopoietinsAnimalsCells, CulturedDose-Response Relationship, DrugFibroblastsHeLa CellsHumansHuman Umbilical Vein Endothelial CellsHypoxia-Inducible Factor 1, alpha SubunitMiceMice, 129 StrainMice, Inbred C57BLMice, KnockoutNeovascularization, PhysiologicAmino Acids, DicarboxylicAngiopoietin-Like Protein 4AngiopoietinsANGPTL4 protein, humanHIF1A protein, humanHypoxia-Inducible Factor 1, alpha Subunitoxalylglycine

Identifiers

PMID26670924
PMCPMC4887665
OpenAlexW2291689937

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.