ArticleIEEE transactions on ultrasonics, ferroelectrics, and frequency control2015
Noninvasive thrombolysis using microtripsy: a parameter study.
Article in IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed.
- MRI for the Assessment of Histotripsy Ablation in a Canine Osteosarcoma Comparative Oncology Model.Ultrasound in medicine & biology · 2026Article
- Emerging Thrombolysis Technologies in Vascular Thrombosis.Journal of clinical medicine · 2025Review
- Treatment envelope of transcranial histotripsy: challenges and strategies to maximize the treatment location profile.Physics in medicine and biology · 2024Article
- Ultrasound Trigger Ce-Based MOF Nanoenzyme For Efficient Thrombolytic Therapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Mechanical High-Intensity Focused Ultrasound (Histotripsy) in Dogs With Spontaneously Occurring Soft Tissue Sarcomas.IEEE transactions on bio-medical engineering · 2023Article
- Characterizing the Ablative Effects of Histotripsy for Osteosarcoma: In Vivo Study in Dogs.Cancers · 2023Article
- A review of the development of histotripsy for extremity tumor ablation with a canine comparative oncology model to inform human treatments.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Article
- Histotripsy ablation for the treatment of feline injection site sarcomas: a first-in-catInternational journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Article
- Histotripsy Ablation of Spontaneously Occurring Canine Bone Tumors In Vivo.IEEE transactions on bio-medical engineering · 2022Article
- Safety Evaluation of a Forward-Viewing Intravascular Transducer for Sonothrombolysis: An in Vitro and ex Vivo Study.Ultrasound in medicine & biology · 2021Article
- Assessment of Collaborative Robot (Cobot)-Assisted Histotripsy for Venous Clot Ablation.IEEE transactions on bio-medical engineering · 2021Article
- Nanodroplet-mediated catheter-directed sonothrombolysis of retracted blood clots.Microsystems & nanoengineering · 2021Article
- Examining the Influence of Low-Dose Tissue Plasminogen Activator on Microbubble-Mediated Forward-Viewing Intravascular Sonothrombolysis.Ultrasound in medicine & biology · 2020Article
- Advances in Sonothrombolysis Techniques Using Piezoelectric Transducers.Sensors (Basel, Switzerland) · 2020Review
- In Vitro Thrombolytic Efficacy of Single- and Five-Cycle Histotripsy Pulses and rt-PA.Ultrasound in medicine & biology · 2020Article
- Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging.Physics in medicine and biology · 2019Article
- Integrated Histotripsy and Bubble Coalescence Transducer for Thrombolysis.Ultrasound in medicine & biology · 2018Article
- Catheter Hydrophone Aberration Correction for Transcranial Histotripsy Treatment of Intracerebral Hemorrhage: Proof-of-Concept.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2017Article
- Non-Invasive Thrombolysis Using Microtripsy in a Porcine Deep Vein Thrombosis Model.Ultrasound in medicine & biology · 2017Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Histotripsy fractionates soft tissue by well-controlled acoustic cavitation using microsecond-long, high-intensity ultrasound pulses. The feasibility of using histotripsy as a noninvasive, drug-free, and image-guided thrombolysis method has been shown previously. A new histotripsy approach, termed microtripsy, has recently been investigated for the thrombolysis application to improve treatment accuracy and avoid potential vessel damage. In this study, we investigated the effects of pulse repetition frequency (PRF) on microtripsy thrombolysis. Microtripsy thrombolysis treatments using different PRFs (5, 50, and 100 Hz) and doses (20, 50, and 100 pulses) were performed on blood clots in an in vitro vessel flow model. To quantitatively evaluate the microtripsy thrombolysis effect, the location of focal cavitation, the incident rate of pre-focal cavitation on the vessel wall, the size and location of the resulting flow channel, and the generated clot debris particles were measured. The results demonstrated that focal cavitation was always well confined in the vessel lumen without contacting the vessel wall for all PRFs. Pre-focal cavitation on the front vessel wall was never observed at 5Hz PRF, but occasionally observed at PRFs of 50 Hz (1.2%) and 100 Hz (5.4%). However, the observed pre-focal cavitation was weak and did not significantly affect the focal cavitation. Results further demonstrated that, although the extent of clot fractionation per pulse was the highest at 5 Hz PRF at the beginning of treatment (<20 pulses), 100 Hz PRF generated the largest flow channels with a much shorter treatment time. Finally, results showed fewer large debris particles were generated at a higher PRF. Overall, the results of this study suggest that a higher PRF (50 or 100 Hz) may be a better choice for microtripsy thrombolysis to use clinically due to the larger resulting flow channel, shorter treatment time, and smaller debris particles.
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