Evidence map›Paper›PMID 26670794›Full record

Trial reportGenetic testing and molecular biomarkers2016

Association of Polymorphisms in Endothelial Nitric Oxide Synthesis and Renin-Angiotensin-Aldosterone System with Developing of Coronary Artery Disease in Bulgarian Patients.

Katya Mokretar, Hristo Velinov, Arman Postadzhiyan, Margarita Apostolova

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Genetic testing and molecular biomarkers, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Correlation ofPharmacogenomics · 2024
    Observational
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
  11. Inhibition of Angiotensin-II Production Increases Susceptibility to Acute Ischemia/Reperfusion Arrhythmia.Medical science monitor : international medical journal of experimental and clinical research · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Katya Mokretar1 Medical and Biological Research Laboratory, Roumen Tzanev Institute of Molecular Biology , Bulgarian Academy of Science, Sofia, Bulgaria .
Hristo Velinov1 Medical and Biological Research Laboratory, Roumen Tzanev Institute of Molecular Biology , Bulgarian Academy of Science, Sofia, Bulgaria .
Arman Postadzhiyan2 University Hospital "St. Anna, " Clinic of Cardiology, Sofia, Bulgaria .
Margarita Apostolova1 Medical and Biological Research Laboratory, Roumen Tzanev Institute of Molecular Biology , Bulgarian Academy of Science, Sofia, Bulgaria .
Institute of Molecular Biology · BGMedical University of Sofia · BG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimThe purpose of this study was to evaluate the association of common polymorphisms in endothelial nitric oxide synthesis (eNOS; G894T) and renin-angiotensin-aldosterone system (angiotensin converting enzyme [ACE]-I/D, angiotensinogen-T704C, and angiotensin II receptor type 1-A1166C) as risk factors in the pathogenesis of coronary artery disease (CAD) in Bulgarian patients.

methodsThis study included 171 patients with CAD and 123 control subjects. Polymerase chain reaction-restriction fragment length polymorphism was used for studying the single-nucleotide polymorphisms. Statistical analysis was performed using statistical software PASW for Windows.

resultsA significantly higher percentage of the eNOS T894 allele was found in patients with acute coronary syndrome (ACS), compared to controls (p = 0.006) and patients with stable angina pectoris (SAP, p = 0.005). Results from a binary regression analysis suggested that eNOS T allele and ACE D allele carriers were more likely to develop ACS than controls (T allele odds ratio [OR] 2.585, p = 0.024; D allele OR 3.585, p = 0.046) and patients with SAP (T allele OR 2.955, p = 0.009; D allele OR 2.703, p = 0.05). Exploratory evaluation of gene-gene combinations showed a significant association between eNOS-G894T/ACE-I/D and ACS compared to controls (p = 0.022) and patients with SAP (p = 0.017).

conclusionsThe eNOS G894T and ACE I/D polymorphisms are associated with an increased risk of developing ACS after adjusting for classical risk factors for atherosclerosis in the Bulgarian cohort.

Indexed as

Polymorphism, Restriction Fragment LengthAdultAgedBulgariaCoronary Artery DiseaseFemaleHumansMaleMiddle AgedNitric Oxide Synthase Type IIIPeptidyl-Dipeptidase ARenin-Angiotensin SystemACE protein, humanNitric Oxide Synthase Type IIINOS3 protein, humanPeptidyl-Dipeptidase A

Identifiers

PMID26670794
PMCPMC4761797
OpenAlexW2211840633

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.