ArticleeLife2015
The cation channel TRPA1 tunes mosquito thermotaxis to host temperatures.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers.
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Who cites it
80 citing papers in PubMed, 149 citations in OpenAlex.
- Recurrent synapses between CO2-sensitive olfactory sensory neurons enable robust CO2 detection in Aedes aegypti mosquitoes.PLoS biology · 2026Article
- The HOST assay: an automated video-based evaluation of mosquito attraction to thermal infrared.Nature protocols · 2026Review
- Optogenetic Analysis of Behavior in the Mosquito Aedes aegypti.Journal of visualized experiments : JoVE · 2026Article
- Gustatory function of Aedes aegypti opsins and TRPA1 in avoiding a natural insect repellent.Current biology : CB · 2026Article
- The sensory biology of mosquito gustation.Current opinion in neurobiology · 2026Review
- Mosquito heat and humidity detection in host seeking and oviposition behavior.Current opinion in neurobiology · 2026Review
- A Molecular and Cellular Mechanism for Bitter Taste in the mosquitobioRxiv : the preprint server for biology · 2026Article
- The Cellular and Circuit Basis of Temperature Sensation inAnnual review of neuroscience · 2026Review
- Optogenetic Analysis of Behavior in the MosquitobioRxiv : the preprint server for biology · 2026Article
- Repellent activity against Aedes aegypti and metabolomic profiling of Myrica gale L. essential oils from Irish boglands.Scientific reports · 2026Article
- Involvement of Multiple Ion Channels and Receptors in Mediating the Insecticidal and Repellent Actions of Limonene.International journal of molecular sciences · 2025Article
- Article
- Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial.bioRxiv : the preprint server for biology · 2025Article
- Time-of-day modulation in mosquito response persistence to carbon dioxide is controlled by Pigment-Dispersing Factor.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- A single-nucleus transcriptomic atlas of the adultbioRxiv : the preprint server for biology · 2025Article
- Recurrent connectivity supports carbon dioxide sensitivity inbioRxiv : the preprint server for biology · 2025Article
- Voltage-gated ion channel TRP/Painless regulates the excretory function of the Malpighian tubules in larval lepidopterans.The Journal of experimental biology · 2025Article
- Neural substrates of cold nociception ineLife · 2025Article
- Exploiting TRP channel diversity in insects: a pathway to next-generation pest management.Archives of toxicology · 2025Review
- Impact of elevated COScientific reports · 2025Article
20 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
While most animals thermotax only to regulate their temperature, female mosquitoes are attracted to human body heat during pursuit of a blood meal. Here we elucidate the basic rules of Aedes aegypti thermotaxis and test the function of candidate thermoreceptors in this important behavior. We show that host-seeking mosquitoes are maximally attracted to thermal stimuli approximating host body temperatures, seeking relative warmth while avoiding both relative cool and stimuli exceeding host body temperature. We found that the cation channel TRPA1, in addition to playing a conserved role in thermoregulation and chemosensation, is required for this specialized host-selective thermotaxis in mosquitoes. During host-seeking, AaegTRPA1(-/-) mutants failed to avoid stimuli exceeding host temperature, and were unable to discriminate between host-temperature and high-temperature stimuli. TRPA1-dependent tuning of thermotaxis is likely critical for mosquitoes host-seeking in a complex thermal environment in which humans are warmer than ambient air, but cooler than surrounding sun-warmed surfaces.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.