Evidence map›Paper›PMID 26670489›Full record

ArticleMalaria journal2015

Exploring health practitioners' acceptability of a prospective semi-quantitative pfHRP2 device to define severe malaria in the Democratic Republic of Congo.

Freek de Haan, Marie A Onyamboko, Caterina I Fanello, Charles J Woodrow, Yoel Lubell, Wouter P C Boon, Arjen M Dondorp

Abstract read
In one paragraph

Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Freek de HaanInnovation Studies Group, Copernicus Institute, Utrecht University, Utrecht, The Netherlands. fdehaan12@gmail.com.
Marie A OnyambokoKinshasa School of Public Health, Kinshasa, Democratic Republic of Congo. akatshimarie@yahoo.fr.
Caterina I FanelloCentre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK. caterina@tropmedres.ac.
Charles J WoodrowCentre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK. charlie@tropmedres.ac.
Yoel LubellCentre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK. yoel@tropmedres.ac.
Wouter P C BoonInnovation Studies Group, Copernicus Institute, Utrecht University, Utrecht, The Netherlands. w.p.c.boon@uu.nl.
Arjen M DondorpCentre for Tropical Medicine, Nuffield Department of Medicine, University of Oxford, Oxford, UK. arjen@tropmedres.ac.

Funding

Wellcome Trust
6 · The paper itself

Abstract

backgroundA rapid diagnostic tool is being developed to discern severely ill children with severe malaria from children who are ill with alternative febrile diseases but have coincidental peripheral blood parasitaemia. The device semi-quantitatively measures plasma pfHRP2 and has the potential to reduce mortality in children with severe febrile illnesses by improving diagnosis. The aim of this study is to identify contributing and inhibiting factors that affect healthcare practitioners' acceptability of this prospective diagnostic device in a high malaria transmission setting in the Democratic Republic of Congo.

methodsData were collected qualitatively by conducting semi-structured interviews with a purposeful sample of health professionals in Kinshasa, capital of Democratic Republic of Congo. In total, 11 interviews were held with professionals at four different institutes.

resultsFour key findings emerged: (1) Congolese practitioners perceive the semi-quantitative pfHRP2 device as a welcome intervention as they recognize the limited reliability of their current diagnostic and therapeutic approaches to severe febrile illnesses; (2) compatibility of the semi-quantitative pfHRP2 device with clinical equipment and competences of Congolese health practitioners is considered to be limited, especially in rural settings; (3) a formal training programme is crucial for correct understanding and application of the semi-quantitative pfHRP2 device; and, (4) provision of evidence to practitioners, and support from health authorities would be important to establish confidence in the semi-quantitative pfHRP2 device.

conclusionsCongolese practitioners perceive the prospective semi-quantitative pfHRP2 device as a welcome addition to their clinical equipment. The device could improve current diagnostic work-up of severe febrile illness, which might consequently improve treatment choices. However, despite this recognized potential, several hurdles and drivers need to be taken into account when implementing this device in DR Congo.

Indexed as

Attitude of Health PersonnelPatient Acceptance of Health CareAntigens, ProtozoanChild, PreschoolDemocratic Republic of the CongoDiagnosis, DifferentialDiagnostic Tests, RoutineHumansInfantInfant, NewbornInterviews as TopicMalaria, FalciparumProtozoan ProteinsAntigens, ProtozoanHRP-2 antigen, Plasmodium falciparumProtozoan Proteins

Identifiers

PMID26670489
PMCPMC4681050

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.