Evidence map›Paper›PMID 26670474›Full record

ArticleThe Journal of allergy and clinical immunology2016

Preserved effector functions of human ORAI1- and STIM1-deficient neutrophils.

Roland Elling, Baerbel Keller, Carl Weidinger, Monika Häffner, Sachin D Deshmukh, Isabelle Zee, Carsten Speckmann, Stephan Ehl, Klaus Schwarz, Stefan Feske and 1 more

Open access · greenAbstract readLetter
In one paragraph

Article in The Journal of allergy and clinical immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 19 citations in OpenAlex.

  1. Neutrophil store-operated CaJournal of cystic fibrosis : official journal of the European Cystic Fibrosis Society · 2025
    Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. ORAI1 and ORAI2 modulate murine neutrophil calcium signaling, cellular activation, and host defense.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Review
  8. Modeling MyD88 DeficiencyFrontiers in immunology · 2020
    Article
  9. Article
  10. Review
  11. Review
  12. ORAI1 mutations abolishing store-operated CaThe Journal of allergy and clinical immunology · 2018
    Article
  13. Review
  14. Article
  15. The role of STIM and ORAI proteins in phagocytic immune cells.American journal of physiology. Cell physiology · 2016
    Review
  16. Store-Operated CaContact (Thousand Oaks (Ventura County, Calif.))
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 2 countries.

Roland EllingCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany; Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Mass. Electronic address: roland.elling@umassmed.edu.
Baerbel KellerCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Carl WeidingerDepartment of Pathology, New York University School of Medicine, New York, NY.
Monika HäffnerCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Sachin D DeshmukhCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Isabelle ZeeDepartment of Pathology, New York University School of Medicine, New York, NY.
Carsten SpeckmannCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Stephan EhlCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany.
Klaus SchwarzInstitute for Clinical Transfusion Medicine and Immunogenetics Ulm, German Red Cross Blood Service Baden-Wuerttemberg-Hessen and Institute for Transfusion Medicine University Ulm, Ulm, Germany.
Stefan FeskeDepartment of Pathology, New York University School of Medicine, New York, NY.
Philipp HennekeCenter for Chronic Immunodeficiency, University Medical Center Freiburg, Freiburg, Germany; Center for Pediatrics and Adolescent Medicine, University Medical Center Freiburg, Freiburg, Germany. Electronic address: philipp.henneke@uniklinik-freiburg.de.
University Medical Center Freiburg · DENew York University · USGerman Red Cross · DEUniversity of Massachusetts Chan Medical School · US

Funding

CRAC Channel Deficiency in Immunity to InfectionR01AI097302 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FESKE, STEFAN · 2012 to 2022
$5.6M
NIAID NIH HHS R01 AI097302
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Loss of Function MutationBiomarkersCase-Control StudiesFlow CytometryHumansImmunologic Deficiency SyndromesNeoplasm ProteinsNeutrophilsORAI1 ProteinStromal Interaction Molecule 1Young AdultBiomarkersNeoplasm ProteinsORAI1 ProteinORAI1 protein, humanSTIM1 protein, humanStromal Interaction Molecule 1

Identifiers

PMID26670474
PMCPMC4860117
OpenAlexW2203130118

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.