ReviewSocial psychiatry and psychiatric epidemiology2016
Toward earlier identification and preventative intervention in schizophrenia: evidence from the London Child Health and Development Study.
Review in Social psychiatry and psychiatric epidemiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 58 citations in OpenAlex.
- Trial
- Psychosocial Interventions, Recovery, and Mediating Mechanisms in Schizophrenia-Spectrum Disorders: A Systematic Review and Meta-Analysis of Longitudinal Studies.Brain sciences · 2026Review
- Clinical and functional outcomes at 7-year follow-up of children presenting putative antecedents of schizophrenia at age 9-12 years.Schizophrenia (Heidelberg, Germany) · 2024Article
- A whole-brain neuromark resting-state fMRI analysis of first-episode and early psychosis: Evidence of aberrant cortical-subcortical-cerebellar functional circuitry.NeuroImage. Clinical · 2024Article
- Measurement invariance across age, gender, ethnicity, and psychopathology of the Psychotic-Like Experiences Questionnaire for Children in a community sample.International journal of methods in psychiatric research · 2023Article
- Influence of stigma, sociodemographic and clinical characteristics on mental health-related service use and associated costs among young people in the United Kingdom.European child & adolescent psychiatry · 2023Article
- Cognitive Dysfunction as a Risk Factor for Psychosis.Current topics in behavioral neurosciences · 2023Article
- Understanding Associations Between Race/Ethnicity, Experiences of Discrimination, and Psychotic-like Experiences in Middle Childhood.Journal of the American Academy of Child and Adolescent Psychiatry · 2022Article
- Developmental profiles of schizotypy in the general population: A record linkage study of Australian children aged 11-12 years.The British journal of clinical psychology · 2022Article
- Dissociable impairments of verbal learning differentiate childhood risk profiles for schizophrenia.Schizophrenia research. Cognition · 2022Article
- Distressing psychotic-like experiences, cognitive functioning and early developmental markers in clinically referred young people aged 8-18 years.Social psychiatry and psychiatric epidemiology · 2022Article
- Persistent and distressing psychotic-like experiences using adolescent brain cognitive development℠ study data.Molecular psychiatry · 2022Article
- Cortisol Levels in Childhood Associated With Emergence of Attenuated Psychotic Symptoms in Early Adulthood.Biological psychiatry · 2022Article
- Early Detection and Prevention of Schizophrenic Psychosis-A Review.Brain sciences · 2021Review
- Contributions of childhood trauma and atypical development to increased clinical symptoms and poor functioning in recent onset psychosis.Early intervention in psychiatry · 2020Article
- Prevention and early intervention in youth mental health: is it time for a multidisciplinary and trans-diagnostic model for care?International journal of mental health systems · 2020Review
- Childhood bullying victimization, self-labelling, and help-seeking for mental health problems.Social psychiatry and psychiatric epidemiology · 2020Article
- Psychometric validation of the self-identification of having a mental illness (SELF-I) scale and the relationship with stigma and help-seeking among young people.Social psychiatry and psychiatric epidemiology · 2019Article
- Assessment of the Prodromal Questionnaire-Brief Child Version for Measurement of Self-reported Psychoticlike Experiences in Childhood.JAMA psychiatry · 2018Article
- Autism: a transdiagnostic, dimensional, construct of reasoning?The European journal of neuroscience · 2018Review
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2 authors at 1 institution in 2 countries.
Funding
Abstract
purposeThe London Child Health and Development Study (CHADS) is a prospective, longitudinal investigation of children, sampled from the general community aged 9-11 years and assessed biennially, who present premorbid risk markers for schizophrenia. The study aims to characterise developmental trajectories of psychological, cognitive, and biological functioning in at-risk children and identify potential targets for early preventative intervention. This review summarises CHADS findings, discusses these in the context of recent theory regarding aetiology and prevention of schizophrenia, and highlights challenges to be addressed with future research.
methodsWe review (1) epidemiological information on the prevalence and correlates of developmental antecedents of schizophrenia in the general child population, (2) evidence of psychosocial, cognitive, and biological dysfunctions in at-risk children presenting multiple antecedents of schizophrenia and at-risk children with a family history of schizophrenia, and (3) related findings from an associated sample of help-seeking children receiving intervention.
resultsCommunity-based screening of 9-11-year olds identified ~9 % with a triad of antecedents of schizophrenia [including psychotic-like experiences (PLEs)] who are putatively at-risk of psychosis; these children reported greater exposure and responsivity to stressors, impairments in general intelligence and specific cognitive functions, brain structure and function abnormalities, and neuromotor dysfunction. Preliminary evidence suggests distressing PLEs are a viable target for cognitive-behavioural intervention in at-risk children.
conclusionsIntervention in early, premorbid phases of illness might alleviate current difficulties and avert future schizophrenia using benign treatments. The CHADS programme has identified several markers that may index early pathophysiology and constitute potential targets for preventative intervention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.