Evidence map›Paper›PMID 26670296›Full record

ArticleNature reviews. Neurology2016

Stroke. Support for IV tPA in ischaemic stroke in elderly people.

Susan W Law, Steven R Levine

Abstract readComment
PubMed Publisher
In one paragraph

Article in Nature reviews. Neurology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Susan W LawStroke Center &Department of Neurology, Kings County Hospital Center &The State University of New York Downstate Medical Center, 451 Clarkson Avenue, Brooklyn, New York, NY-11203, USA.
Steven R LevineStroke Center &Department of Neurology, Kings County Hospital Center &The State University of New York Downstate Medical Center, 451 Clarkson Avenue, Brooklyn, New York, NY-11203, USA.

Funding

State University of New York (SUNY) NEXT Clinical SiteU10NS077378 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI LEVINE, STEVEN RICHARD · 2011 to 2017
$2.1M
State University of New York (SUNY) Downstate NETT Clinical Site HubU10NS080377 · NINDS · SUNY DOWNSTATE MEDICAL CENTER · PI LEVINE, STEVEN RICHARD · 2012 to 2016
$1.4M
NINDS NIH HHS U10 NS077378NINDS NIH HHS U10 NS080377
6 · The paper itself

Abstract

In Europe, use of intravenous tissue plasminogen activator (tPA) in patients older than 80 years is discouraged because these patients have been excluded from certain past clinical trials. A new retrospective, observational study shows that tPA can substantially improve functional outcome after ischaemic stroke in patients aged 80–89 years.

Indexed as

Treatment OutcomeAgedBrain IschemiaEuropeFibrinolytic AgentsHumansRetrospective StudiesStrokeThrombolytic TherapyFibrinolytic Agents

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.