ArticleTranslational psychiatry2015
An improved human anxiety process biomarker: characterization of frequency band, personality and pharmacology.
Article in Translational psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 65 citations in OpenAlex.
- Ketamine effects on EEG and their links to therapy differ across treatment-resistant major depression, post-traumatic stress disorder, and obsessive-compulsive disorder.The international journal of neuropsychopharmacology · 2026Article
- Hope for Neurotic Disorders: A Summary of New Zealand Research on the Development of Biomarkers and Novel Treatments.Journal of the Royal Society of New Zealand · 2026Article
- Neural mechanisms underlying cognitive inflexibility in obsessive-compulsive disorder: a review.Frontiers in psychiatry · 2026Review
- A four-factor model of psychopathy assessed via neural reinforcement sensitivity theory.Personality neuroscience · 2026Article
- Perspective: Hippocampal theta rhythm as a potential vestibuloacoustic biomarker of anxiety.The European journal of neuroscience · 2025Review
- Personality and Psychoneuroimmunology: A Systems Biology Perspective.Methods in molecular biology (Clifton, N.J.) · 2025Review
- Is lack of goal-conflict-specific rhythmicity a biomarker for treatment resistance in generalised anxiety but not social anxiety or major depression?Journal of psychopharmacology (Oxford, England) · 2024Article
- Midfrontal conflict theta and parietal P300 are linked to a latent factor of DSM externalising disorders.Personality neuroscience · 2024Article
- Midfrontal theta reactivity to conflict and error are linked to externalizing and internalizing respectively.Personality neuroscience · 2024Article
- Utility of Cognitive Neural Features for Predicting Mental Health Behaviors.Sensors (Basel, Switzerland) · 2022Article
- Neuropsychological Theory as a Basis for Clinical Translation of Animal Models of Neuropsychiatric Disorder.Frontiers in behavioral neuroscience · 2022Article
- Right Frontal Theta: Is It a Response Biomarker for Ketamine's Therapeutic Action in Anxiety Disorders?Frontiers in neuroscience · 2022Article
- Non-human contributions to personality neuroscience - from fish through primates. An introduction to the special issue.Personality neuroscience · 2022Review
- Right frontal anxiolytic-sensitive EEG 'theta' rhythm in the stop-signal task is a theory-based anxiety disorder biomarker.Scientific reports · 2021Article
- Goal-Conflict EEG Theta and Biased Economic Decisions: A Role for a Second Negative Motivation System.Frontiers in neuroscience · 2020Article
- Personality neuroscience and psychopathology: should we start with biology and look for neural-level factors?Personality neuroscience · 2020Review
- Increases in theta CSD power and coherence during a calibrated stop-signal task: implications for goal-conflict processing and the Behavioural Inhibition System.Personality neuroscience · 2019Article
- Does behavioural inhibition system dysfunction contribute to Attention Deficit Hyperactivity Disorder?Personality neuroscience · 2019Article
- Anxiety as a Common Biomarker for School Children With Additional Health and Developmental Needs Irrespective of Diagnosis.Frontiers in psychology · 2019Article
- Ketamine Effects on EEG during Therapy of Treatment-Resistant Generalized Anxiety and Social Anxiety.The international journal of neuropsychopharmacology · 2018Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety disorders are among the most common mental illness in the western world with a major impact on disability. But their diagnosis has lacked objective biomarkers. We previously demonstrated a human anxiety process biomarker, goal-conflict-specific electroencephalography (EEG) rhythmicity (GCSR) in the stop-signal task (SST). Here we have developed and characterized an improved test appropriate for clinical group testing. We modified the SST to produce balanced numbers of trials in clearly separated stop-signal delay groups. As previously, right frontal (F8) GCSR was extracted as the difference in EEG log Fourier power between matching stop and go trials (that is, stop-signal-specific power) of a quadratic contrast of the three delay values (that is, power when stopping and going are in balanced conflict compared with the average of when stopping or going is greater). Separate experiments assessed drug sensitivity (n=34) and personality relations (n=59). GCSR in this new SST was reduced by three chemically distinct anxiolytic drugs (administered double-blind): buspirone (10 mg), triazolam (0.25 mg) and pregabalin (75 mg); had a frequency range (4-12 Hz) consistent with rodent model data; and positively correlated significantly with neuroticism and nonsignificantly with trait anxiety scores. GCSR, measured in our new form of the SST, should be suitable as a biomarker for one specific anxiety process in the testing of clinical groups and novel drugs and in the development of measures suitable for individual diagnosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.