ArticleLearning & memory (Cold Spring Harbor, N.Y.)2016
Individual differences in the expression of conditioned fear are associated with endogenous fibroblast growth factor 2.
Article in Learning & memory (Cold Spring Harbor, N.Y.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Impacts of sex and the estrous cycle on associations between post-fear conditioning sleep and fear memory recall.Behavioural brain research · 2020Article
- Individual differences in conditioned fear are associated with levels of adolescent/early adult alcohol consumption and instrumental extinction.Behavioural brain research · 2018Article
- Selectively Bred Rats Provide a Unique Model of Vulnerability to PTSD-Like Behavior and Respond Differentially to FGF2 Augmentation Early in Life.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Individual differences in fear extinction and anxiety-like behavior.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- Fibroblast Growth Factor-2: A Promising Biomarker for Anxiety and Trauma Disorders.Journal of experimental neuroscience · 2017Article
- The Association Between Salivary FGF2 and Physiological and Psychological Components of the Human Stress Response.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
These experiments examined the relationship between the neurotrophic factor fibroblast growth factor 2 (FGF2) and individual differences in the expression of conditioned fear. Experiments 1 and 2 demonstrated that rats naturally expressing low levels of contextual or cued fear have higher levels of hippocampal FGF2 relative to rats that express high levels of conditioned fear and nonconditioned rats. Experiment 3 demonstrated that hippocampal FGF2 is not increased in rats that exhibit pharmacological-induced amnesia of conditioned fear. Together, these experiments provide evidence that FGF2 may be an endogenous regulator of fear responses to conditioned stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.