ArticleInfection2016
Diagnosis of blood culture-negative endocarditis and clinical comparison between blood culture-negative and blood culture-positive cases.
Article in Infection, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05791357 (The Role of Polymerase Chain Reaction in the Management of Patients With Infective Endocarditis), which is not on this map. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Role of Polymerase Chain Reaction in the Management of Patients With Infective Endocarditis: Modern Diagnostic and Therapeutic Concepts
Who cites it
41 citing papers in PubMed, 103 citations in OpenAlex.
- Impacts of blood culture-negative status on outcomes of infectious endocarditis patients with nonsurgical and surgical intervention.Medicine · 2026Article
- Disseminated Bartonellosis Masquerading as Autoimmune Glomerulonephritis: A Case Report.Case reports in nephrology · 2026Article
- Indicators of In-Hospital Mortality in Infective Endocarditis: A Single-Center Retrospective Study.Cureus · 2026Article
- Long-Term Prognosis and Surgical Outcomes of Culture-Negative Infective Endocarditis.Journal of the American Heart Association · 2025Article
- Review
- Diagnostic work-up and current management strategies for infective endocarditis in the pediatric population.Indian journal of thoracic and cardiovascular surgery · 2024Review
- Culture-negative endocarditis with multifocal spread and flail mitral valve leaflet: a case report.Annals of medicine and surgery (2012) · 2024Article
- Comparison of Blood-Based Shotgun and Targeted Metagenomic Sequencing for Microbiological Diagnosis of Infective Endocarditis.Open forum infectious diseases · 2023Article
- A Dual-Pathogen Mitral Valve Endocarditis Caused byPathogens (Basel, Switzerland) · 2023Article
- Updates in Culture-Negative Endocarditis.Pathogens (Basel, Switzerland) · 2023Review
- Evaluation of Infective Endocarditis in Children: A 19-Year Retrospective Study in Taiwan.Journal of clinical medicine · 2023Article
- Molecular epidemiology of Bartonella quintana endocarditis in patients from Israel and Eastern Africa.BMC infectious diseases · 2023Article
- CASSIA (cardiology software suite for image analysis): a potential new tool for the evaluation of [International journal of computer assisted radiology and surgery · 2023Article
- Infective Endocarditis: Predictive Factors for Diagnosis and Mortality in Surgically Treated Patients.Journal of cardiovascular development and disease · 2022Article
- Utility of Metagenomic Next-Generation Sequencing in Infective Endocarditis: A Systematic Review.Antibiotics (Basel, Switzerland) · 2022Review
- Article
- Injection drug induced septic embolism-A growing concern.Radiology case reports · 2022Article
- Molecular and Serological Diagnostic Approach to Define the Microbiological Origin of Blood Culture-Negative Infective Endocarditis.Pathogens (Basel, Switzerland) · 2022Article
- Pathogen Detection in Infective Endocarditis Using Targeted Metagenomics on Whole Blood and Plasma: a Prospective Pilot Study.Journal of clinical microbiology · 2022Article
- Antibiotics and Missed Etiological Diagnosis of Infective Endocarditis: A Dangerous Duo.Journal of clinical medicine · 2022Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo analyze the clinical characteristics of blood culture-negative endocarditis (BCNE) and how it compares to those of blood culture-positive endocarditis (BCPE) cases and show how molecular tools helped establish the etiology in BCNE.
methodsAdult patients with definite infective endocarditis (IE) and having valve surgery were included. Valves were studied by polymerase chain reaction (PCR). Statistical analysis compared BCNE and BCPE.
resultsOne hundred and thirty-one patients were included; 53 (40 %) had BCNE. The mean age was 45 ± 16 years; 33 (62 %) were male. BCNE was community-acquired in 41 (79 %). Most patients were referred from other hospitals (38, 73 %). Presentation was subacute in 34 (65 %), with fever in 47/53 (90 %) and a new regurgitant murmur in 34/42 (81 %). Native valves were affected in 74 %, mostly left-sided. All echocardiograms showed major criteria for IE. Antibiotics were used prior to BC collection in 31/42 (74 %). Definite histological diagnosis was established for 35/50 (70 %) valves. PCR showed oralis group streptococci in 21 (54 %), S. aureus in 3 (7.7 %), gallolyticus group streptococci in 2 (5.1 %), Coxiella burnetii in 1 (2.5 %) and Rhizobium sp. in 1 (2.5 %). In-hospital mortality was 9/53 (17 %). Fever (p = 0.06, OR 4.7, CI 0.91-24.38) and embolic complications (p = 0.003, OR 3.3, CI 1.55-6.82) were more frequent in BCPE cases, while new acute regurgitation (p = 0.05, OR 0.3, CI 0.098-0.996) and heart failure (p = 0.02, OR 0.3, CI 0.13-0.79) were less so.
conclusionsBCNE resulted mostly from prior antibiotics and was associated with severe hemodynamic compromise. Valve histopathology and PCR were useful in confirming the diagnosis and pointing to the etiology of BCNE.
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Registered trials
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