Observational studyEuropean journal of pediatrics2016
Strategies implementation to reduce medicine preparation error rate in neonatal intensive care units.
Observational study in European journal of pediatrics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Prevalence, Causes and Severity of Medication Administration Errors in the Neonatal Intensive Care Unit: A Systematic Review and Meta-Analysis.Drug safety · 2022Pooled it
- Interventions to Reduce Medication Dispensing, Administration, and Monitoring Errors in Pediatric Professional Healthcare Settings: A Systematic Review.Frontiers in pediatrics · 2021Pooled it
- The Effect of Standard Concentration Infusions on Medication Errors in Neonatal and Pediatric Healthcare Settings: A Systematic Review.Journal of clinical medicine · 2025Review
- Intravenous drug use in neonatal intensive care units.European journal of hospital pharmacy : science and practice · 2021Observational
- Patterns of Safety Incidents in a Neonatal Intensive Care Unit.Frontiers in pediatrics · 2021Article
- Intravenous medicine preparation technique training programme for nurses in clinical areas.European journal of hospital pharmacy : science and practice · 2018Review
- Interventions to reduce medication errors in neonatal care: a systematic review.Therapeutic advances in drug safety · 2018Review
- Neonates and medicines: a roadmap to further improve neonatal pharmaceutical care.European journal of pediatrics · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledThis study assessed the rate of errors in intravenous medicine preparation at bedside in neonatal intensive care units versus preparation error rate in a hospital pharmacy service before and after several strategies were implemented. We performed a prospective observational study during 2013-2015. Ten Spanish neonatal intensive care units and one hospital pharmacy service participated in the study. Two types of preparation errors were considered, calculation errors and accuracy errors. The study was carried out over three consecutive phases: (1) pre-intervention phase, when medicine preparation samples were collected from neonatal intensive care units and hospital pharmacy service according to their normal clinical practice; (2) intervention phase, when protocol standardisation and educational strategy took place; and (3) post-intervention phase, when new medicine samples were collected after strategy implementation. In neonatal intensive care units, 1.35 % of samples registered calculation errors in pre-intervention phase; no calculation errors were registered in hospital pharmacy service samples. In post-intervention phase, no calculation errors were registered in either group. Accuracy error rate decreased both in neonatal intensive care units (54.7 vs 23 %) and hospital pharmacy service (38.3 vs 14.6 %).
conclusionCalculation errors can disappear with good standardisation protocols. Decrease in accuracy error depends on good preparation technique and environmental factors. WHAT IS KNOWN: • Medication use is associated with a risk of errors and adverse events. Medication errors are more frequent and have more severe consequences in paediatric patients. • Lack of commercial drug formulations adapted to newborn infants makes medicine preparation process more prone to error. What is New: • Calculation errors are minimising using concentration standard protocols. Preparation rules are essential to ensure the accuracy process. • Environmental conditions affect the accuracy process.
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