Trial reportPloS one2015
Salivary Oxytocin Concentrations in Males following Intranasal Administration of Oxytocin: A Double-Blind, Cross-Over Study.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 93 citations in OpenAlex.
- Chronic oxytocin administration stimulates the oxytocinergic system in children with autism.Nature communications · 2024Trial
- Intranasal oxytocin modulates the salience network in aging.NeuroImage · 2022Trial
- Changes in the cortisol and oxytocin levels of first-time pregnant women during interaction with an infant: a randomized controlled trial.BMC pregnancy and childbirth · 2021Trial
- In the nose or on the tongue? Contrasting motivational effects of oral and intranasal oxytocin on arousal and reward during social processing.Translational psychiatry · 2021Trial
- Oxytocin Enhances an Amygdala Circuit Associated With Negative Symptoms in Schizophrenia: A Single-Dose, Placebo-Controlled, Crossover, Randomized Control Trial.Schizophrenia bulletin · 2020Trial
- How does oxytocin modulate human behavior?Molecular psychiatry · 2025Review
- Endogenous Oxytocin and Depressive Symptoms in Drug Abstainers: The Roles of Perceived Social Support and Drug Abstinence Self-Efficacy.Psychology research and behavior management · 2025Article
- Oromucosal Administration of Oxytocin: The Development of 'Oxipops'.Pharmaceutics · 2024Review
- Changes in Salivary Oxytocin Level of Term Pregnant Women after Aromatherapy Footbath for Spontaneous Labor Onset: A Non-Randomized Experimental Study.International journal of environmental research and public health · 2023Article
- Frequency-Tagging EEG of Superimposed Social and Non-Social Visual Stimulation Streams Provides No Support for Social Salience Enhancement after Intranasal Oxytocin Administration.Brain sciences · 2022Article
- Oxytocin administration versus emotion training in healthy males: considerations for future research.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Temporal Dynamics of Intranasal Oxytocin in Human Brain Electrophysiology.Cerebral cortex (New York, N.Y. : 1991) · 2022Review
- Hormonal Profile in Response to an Empathic Induction Task in Perpetrators of Intimate Partner Violence: Oxytocin/Testosterone Ratio and Social Cognition.International journal of environmental research and public health · 2022Article
- Oxytocin has 'tend-and-defend' functionality in group conflict across social vertebrates.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Effects of Intranasal Administration of Oxytocin and Vasopressin on Social Cognition and Potential Routes and Mechanisms of Action.Pharmaceutics · 2022Review
- Salivary oxytocin in autistic patients and in patients with intellectual disability.Frontiers in psychiatry · 2022Article
- Discussions and perspectives regarding oxytocin as a biomarker in human investigations.Heliyon · 2021Review
- Hormonal and Neurological Aspects of Dog Walking for Dog Owners and Pet Dogs.Animals : an open access journal from MDPI · 2021Article
- Article
- Development of Social Attention and Oxytocin Levels in Maltreated Children.Scientific reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
The use of intranasal oxytocin (OT) in research has become increasingly important over the past decade. Although researchers have acknowledged a need for further investigation of the physiological effects of intranasal administration, few studies have actually done so. In the present double-blind cross-over study we investigated the longevity of a single 24 IU dose of intranasal OT measured in saliva in 40 healthy adult males. Salivary OT concentrations were significantly higher in the OT condition, compared to placebo. This significant difference lasted until the end of testing, approximately 108 minutes after administration, and peaked at 30 minutes. Results showed significant individual differences in response to intranasal OT administration. To our knowledge this is the largest and first all-male within-subjects design study to demonstrate the impact of intranasal OT on salivary OT concentrations. The results are consistent with previous research in suggesting that salivary OT is a valid matrix for OT measurement. The results also suggest that the post-administration 'wait-time' prior to starting experimental tasks could be reduced to 30 minutes, from the 45 minutes typically used, thereby enabling testing during peak OT concentrations. Further research is needed to ascertain whether OT concentrations after intranasal administration follow similar patterns in females, and different age groups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.