ArticleScientific reports2015
The global landscape of cognition: hierarchical aggregation as an organizational principle of human cortical networks and functions.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 1 of them a synthesis that pooled it.
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Who cites it
35 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Macroscale Gradient Dysfunction in Alzheimer's Disease: Patterns With Cognition Terms and Gene Expression Profiles.Human brain mapping · 2024Pooled it
- Reconfiguration of functional brain hierarchy in schizophrenia.Translational psychiatry · 2025Article
- Alterations in the functional MRI-based temporal brain organisation in individuals with obesity.Diabetes, obesity & metabolism · 2025Article
- Multimodal gradients unify local and global cortical organization.Nature communications · 2025Article
- Mindfulness, cognition, and long-term meditators: Toward a science of advanced meditation.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- An Integrated theory of false insights and beliefs under psychedelics.Communications psychology · 2024Review
- Connectome gradient dysfunction contributes to white matter hyperintensity-related cognitive decline.CNS neuroscience & therapeutics · 2024Article
- Differences of individual gray matter networks between MCI patients who converted to AD within 3 Years and nonconverters.Heliyon · 2024Article
- Hierarchical consciousness: the Nested Observer Windows model.Neuroscience of consciousness · 2024Article
- Graded functional organization in the left inferior frontal gyrus: evidence from task-free and task-based functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Investigation of advanced mindfulness meditation "cessation" experiences using EEG spectral analysis in an intensively sampled case study.Neuropsychologia · 2023Article
- Hierarchical growth in neural networks structure: Organizing inputs by Order of Hierarchical Complexity.PloS one · 2023Article
- Cortical hierarchy disorganization in major depressive disorder and its association with suicidality.Frontiers in psychiatry · 2023Article
- Sensory Target Detection at Local and Global Timescales Reveals a Hierarchy of Supramodal Dynamics in the Human Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Intrinsic dynamics and topography of sensory input systems.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Patterns of functional connectivity alterations induced by alcohol reflect somatostatin interneuron expression in the human cerebral cortex.Scientific reports · 2022Article
- Ultimate Grounding of Abstract Concepts: A Graded Account.Journal of cognition · 2022Article
- The brain and its time: intrinsic neural timescales are key for input processing.Communications biology · 2021Review
- Integrating across neuroimaging modalities boosts prediction accuracy of cognitive ability.PLoS computational biology · 2021Article
- Analysis and tuning of hierarchical topic models based on Renyi entropy approach.PeerJ. Computer science · 2021Article
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Authors and funding
4 authors.
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Abstract
Though widely hypothesized, limited evidence exists that human brain functions organize in global gradients of abstraction starting from sensory cortical inputs. Hierarchical representation is accepted in computational networks, and tentatively in visual neuroscience, yet no direct holistic demonstrations exist in vivo. Our methods developed network models enriched with tiered directionality, by including input locations, a critical feature for localizing representation in networks generally. Grouped primary sensory cortices defined network inputs, displaying global connectivity to fused inputs. Depth-oriented networks guided analyses of fMRI databases (~17,000 experiments;~1/4 of fMRI literature). Formally, we tested whether network depth predicted localization of abstract versus concrete behaviors over the whole set of studied brain regions. For our results, new cortical graph metrics, termed network-depth, ranked all databased cognitive function activations by network-depth. Thus, we objectively sorted stratified landscapes of cognition, starting from grouped sensory inputs in parallel, progressing deeper into cortex. This exposed escalating amalgamation of function or abstraction with increasing network-depth, globally. Nearly 500 new participants confirmed our results. In conclusion, data-driven analyses defined a hierarchically ordered connectome, revealing a related continuum of cognitive function. Progressive functional abstraction over network depth may be a fundamental feature of brains, and is observed in artificial networks.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.