ReviewParasitology research1989
The role of free oxygen radicals in the expulsion of primary infections of Nippostrongylus brasiliensis.
Review in Parasitology research, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 26 citations in OpenAlex.
- Effects of Dietary Taurine Supplementation to Gilts during Late Gestation and Lactation on Offspring Growth and Oxidative Stress.Animals : an open access journal from MDPI · 2019Article
- Intestinal IFN-γ production is associated with protection from clinical signs, but not with elimination of worms, in Echinostoma caproni infected-mice.Parasitology research · 2014Article
- Effect of selenium and vitamin E on oxidative stress in lambs experimentally infected with Haemonchus contortus.Veterinary research communications · 2010Article
- cDNA cloning and expression patterns of a peroxiredoxin, a catalase and a glutathione peroxidase from Haemonchus contortus.Parasitology research · 2004Article
- A role for protein kinase C in the production of free oxygen radicals in response to Nippostrongylus brasiliensis.Parasitology research · 1991Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The many and varied pathological, immunological and physiological manifestations of infection with Nippostrongylus brasiliensis may be unified by considering the role of leukocyte-generated free oxygen radicals in worm expulsion. Aside from directly damaging the adult stage of N.brasiliensis and possibly leading to its elimination from the small intestine, free radicals may also damage intestinal cells, thereby contributing to the gut pathology characteristic of infection. gamma-Interferon (and possibly tumour necrosis factor) may be involved in the initiation of free radical generation in response to N. brasiliensis and may also contribute to various side effects of infection such as hypertriglyceridaemia and cachexia. gamma-Interferon may initiate free radical generation via the agency of protein kinase C, an enzyme that can induce various additional responses including lysosomal enzyme and amine secretion and arachidonic acid metabolism. The possible interactions between these mediators and free radicals are subtle and diverse and may profoundly affect the course of infection.
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Registered trials
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