Evidence map›Paper›PMID 26669667›Full record

Trial reportScientific reports2015

Smokeless tobacco consumption impedes metabolic, cellular, apoptotic and systemic stress pattern: A study on Government employees in Kolkata, India.

Sushobhan Biswas, Krishnendu Manna, Ujjal Das, Amitava Khan, Anirban Pradhan, Aaveri Sengupta, Surajit Bose, Saurabh Ghosh, Sanjit Dey

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Sushobhan BiswasDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Krishnendu MannaDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Ujjal DasDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Amitava KhanDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Anirban PradhanDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Aaveri SenguptaDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Surajit BoseDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
Saurabh GhoshHuman Genetics Unit, Indian Statistical Institute, 203 B.T. Road, Kolkata 700 108, West Bengal, India.
Sanjit DeyDepartment of Physiology, University of Calcutta, 92, A.P.C Road, Kolkata 700009, West Bengal, India.
University of Calcutta · INIndian Statistical Institute · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Smokeless tobacco (SLT) remains a threat amongst a large population across the globe and particularly in India. The oral use of tobacco has been implicated to cause physiological stress leading to extreme toxicological challenge. The study included 47 SLT-users and 44 non-users providing a spectrum of pathophysiological, clinico-biochemical, antioxidant parameters, cell cycle progression study of PBMC and morphological changes of red blood cells (RBC). The expressions of p53, p21, Bax, Bcl-2, IL-6, TNF- α, Cox-2, iNOS were analyzed from thirteen representative SLT-users and twelve non-users. Difference in CRP, random glucose, serum cholesterol, TG, HLDL-C, LDL-C, VLDL-C, neutrophil count, monocyte count, ESR, SOD (PBMC) and TBARS (RBC membrane) were found to be statistically significant (p < 0.05) between the studied groups. The current study confers crucial insight into SLT mediated effects on systemic toxicity and stress. This has challenged the metabolic condition leading to a rise in the inflammatory status, increased apoptosis and RBC membrane damage. The above findings were substantiated with metabolic, clinical and biochemical parameters. This is possibly the first ever in-depth report and remains an invaluable document on the fatal effects of SLT.

Indexed as

AdultApoptosisbcl-2-Associated X ProteinCyclin-Dependent Kinase Inhibitor p21Cyclooxygenase 2ErythrocytesFemaleHumansIndiaInterleukin-6Leukocytes, MononuclearLipidsMaleNitric Oxide Synthase Type IIProto-Oncogene Proteins c-bcl-2Stress, PhysiologicalBAX protein, humanbcl-2-Associated X ProteinBCL2 protein, humanCDKN1A protein, humanCyclin-Dependent Kinase Inhibitor p21Cyclooxygenase 2IL6 protein, humanInterleukin-6LipidsNitric Oxide Synthase Type IINOS2 protein, humanProto-Oncogene Proteins c-bcl-2PTGS2 protein, humanTP53 protein, humanTumor Necrosis Factor-alphaTumor Suppressor Protein p53

Identifiers

PMID26669667
PMCPMC4680924
OpenAlexW2215596256

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.