ArticleScientific reports2015
Melatonin Has An Ergogenic Effect But Does Not Prevent Inflammation and Damage In Exhaustive Exercise.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- The Effects of Melatonin Supplementation on Professional Football Player Performance: A Systematic Review.Nutrients · 2023Pooled it
- Influence of Acute Melatonin Administration on Human Physical Performance: A Systematic Review.Sports healthPooled it
- Benefits of self-paced concurrent training on lung function, cardiopulmonary fitness and fatigue perception in patients with multiple sclerosis.Neurodegenerative disease management · 2024Trial
- Effects of melatonin on muscle and liver bioenergetic profiles: focus on acylcarnitines following endurance swimming exercise in rats.Hormones (Athens, Greece) · 2026Article
- Melatonin Supplementation Enhances Next-Day High-Intensity Exercise Performance and Recovery in Trained Males: A Placebo-Controlled Crossover Study.Sports (Basel, Switzerland) · 2025Article
- Effects of Melatonin Administration on Physical Performance and Biochemical Responses Following Exhaustive Treadmill Exercise.Current issues in molecular biology · 2024Article
- L-Glutamine is better for treatment than prevention in exhaustive exercise.Frontiers in physiology · 2023Article
- Effect of acute swimming exercise at different intensities but equal total load over metabolic and molecular responses in swimming rats.Journal of muscle research and cell motility · 2022Article
- Effects of melatonin ingestion on physical performance and biochemical responses following exhaustive running exercise in soccer players.Biology of sport · 2022Article
- Melatonin signalling in Schwann cells during neuroregeneration.Frontiers in cell and developmental biology · 2022Review
- Melatonin Potentiates Exercise-Induced Increases in Skeletal Muscle PGC-1Frontiers in physiology · 2022Article
- Antioxidant supplements and endurance exercise: Current evidence and mechanistic insights.Redox biology · 2020Review
- Review
- Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2020Article
- Article
- Effects of melatonin on oxidative stress parameters and pathohistological changes in rat skeletal muscle tissue following carbon tetrachloride application.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018Article
- The effect of melatonin on endothelial dysfunction in patient undergoing coronary artery bypass grafting surgery.Advanced biomedical research · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is well documented that exhaustive physical exercise leads to inflammation and skeletal muscle tissue damage. With this in mind, melatonin has been acutely administered before physical exercise; nevertheless, the use of melatonin as an ergogenic agent to prevent tissue inflammation and damage remains uncertain. We evaluated the effects of melatonin on swimming performance, muscle inflammation and damage and several physiological parameters after exhaustive exercise at anaerobic threshold intensity (iLAn) performed during light or dark circadian periods. The iLAn was individually determined and two days later, the animals performed an exhaustive exercise bout at iLAn 30 minutes after melatonin administration. The exercise promoted muscle inflammation and damage, mainly during the dark period, and the exogenous melatonin promoted a high ergogenic effect. The expressive ergogenic effect of melatonin leads to longer periods of muscle contraction, which superimposes a possible melatonin protective effect on the tissue damage and inflammation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.