ArticleProceedings of the National Academy of Sciences of the United States of America2015
The terminal phycobilisome emitter, LCM: A light-harvesting pigment with a phytochrome chromophore.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35 citing papers in PubMed.
- Cyanobacteria-derived near-infrared autofluorescent exosomes enabling synergistic brain lesion imaging and neuroprotection.Bioactive materials · 2026Article
- Mechanisms of Red-Shifted Absorption in Biliverdin-Binding Proteins.Biochemistry · 2026Article
- Structure and quenching of a bundle-shaped phycobilisome.Science advances · 2025Article
- The molecular basis of the most red-shifted allophycocyanin discovered to date.Photosynthesis research · 2025Article
- Molecular glue for phycobilisome attachment to photosystem II inProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Crystallographic and biochemical analyses of a far-red allophycocyanin to address the mechanism of the super-red-shift.Photosynthesis research · 2024Article
- Intramolecular charge transfer and the function of vibronic excitons in photosynthetic light harvesting.Photosynthesis research · 2024Review
- Structural comparison of allophycocyanin variants reveals the molecular basis for their spectral differences.Photosynthesis research · 2024Article
- Molecular origins of absorption wavelength variation among phycocyanobilin-binding proteins.Biophysical journal · 2024Article
- Structural and quantum chemical basis for OCP-mediated quenching of phycobilisomes.Science advances · 2024Article
- Article
- Global Landscape of Native Protein Complexes in Synechocystis sp. PCC 6803.Genomics, proteomics & bioinformatics · 2022Article
- Core and rod structures of a thermophilic cyanobacterial light-harvesting phycobilisome.Nature communications · 2022Article
- Here comes the sun: How optimization of photosynthetic light reactions can boost crop yields.Journal of integrative plant biology · 2022Review
- The Red Edge: Bilin-Binding Photoreceptors as Optogenetic Tools and Fluorescence Reporters.Chemical reviews · 2021Review
- Article
- Difference in light use strategy in red alga between Griffithsia pacifica and Porphyridium purpureum.Scientific reports · 2021Article
- Ultrafast energy transfer dynamics of phycobilisome from Thermosynechococcus vulcanus, as revealed by ps fluorescence and fs pump-probe spectroscopies.Photosynthesis research · 2021Article
- The structural basis of far-red light absorbance by allophycocyanins.Photosynthesis research · 2021Article
- Spectroscopic and Photophysical Investigation of Model Dipyrroles Common to Bilins: Exploring Natural Design for Steering Torsion to Divergent Functions.Frontiers in chemistry · 2021Article
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11 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Photosynthesis relies on energy transfer from light-harvesting complexes to reaction centers. Phycobilisomes, the light-harvesting antennas in cyanobacteria and red algae, attach to the membrane via the multidomain core-membrane linker, L(CM). The chromophore domain of L(CM) forms a bottleneck for funneling the harvested energy either productively to reaction centers or, in case of light overload, to quenchers like orange carotenoid protein (OCP) that prevent photodamage. The crystal structure of the solubly modified chromophore domain from Nostoc sp. PCC7120 was resolved at 2.2 Å. Although its protein fold is similar to the protein folds of phycobiliproteins, the phycocyanobilin (PCB) chromophore adopts ZZZssa geometry, which is unknown among phycobiliproteins but characteristic for sensory photoreceptors (phytochromes and cyanobacteriochromes). However, chromophore photoisomerization is inhibited in L(CM) by tight packing. The ZZZssa geometry of the chromophore and π-π stacking with a neighboring Trp account for the functionally relevant extreme spectral red shift of L(CM). Exciton coupling is excluded by the large distance between two PCBs in a homodimer and by preservation of the spectral features in monomers. The structure also indicates a distinct flexibility that could be involved in quenching. The conclusions from the crystal structure are supported by femtosecond transient absorption spectra in solution.
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