Evidence map›Paper›PMID 26669265›Full record

ArticleChemistry (Weinheim an der Bergstrasse, Germany)2016

Ruthenium-Catalyzed Multicomponent Reactions: Access to α-Silyl-β-Hydroxy Vinylsilanes, Stereodefined 1,3-Dienes, and Cyclohexenes.

Barry M Trost, Dennis C Koester, Ehesan U Sharif

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry (Weinheim an der Bergstrasse, Germany), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Barry M TrostDepartment of Chemistry, Stanford University, Stanford, California, 94305-5080, USA. bmtrost@stanford.edu.ORCID http://orcid.org/0000-0001-7369-9121
Dennis C KoesterDepartment of Chemistry, Stanford University, Stanford, California, 94305-5080, USA.
Ehesan U SharifDepartment of Chemistry, Stanford University, Stanford, California, 94305-5080, USA.

Funding

NOVEL SYNTHETIC APPROACHES TO ANTITUMOR COMPOUNDSR01GM033049 · NIGMS · UNIVERSITY OF WISCONSIN MADISON · PI TROST, BARRY M · 1985 to 2016
$6.5M
NIGMS NIH HHS GM 033049NIGMS NIH HHS R01 GM033049
6 · The paper itself

Abstract

The synthesis of densly functionized α-silyl-β-hydroxyl vinylsilanes via ruthenium-catalyzed multicomponent reaction (MCR) is reported herein. Exceptionally high regio- and diastereoselectivity was achieved by employing an unprecedented hydrosilylation of bifunctional silyl-propargyl boronates. The simple protocol, mild reaction conditions, and unique tolerability of this method make it a valuable tool for the synthesis of highly elaborated building blocks. The one-pot synthesis of stereodefined olefins, the generation of a valuable cyclohexene building block through a four-component MCR, and further functionalization in an abundance of diastereoselective reactions is disclosed herein.

Indexed as

AlkenesCyclohexenesMolecular StructureRutheniumSilanesStereoisomerismVinyl CompoundsAlkenesCyclohexenesRutheniumSilanesVinyl Compoundsvinylsilanecatalysisdienesrutheniumsilanesstereoselectivity

Identifiers

PMID26669265
PMCPMC4866645

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.