ArticleUnited European gastroenterology journal2015
Myenteric plexitis: A frequent feature in patients undergoing surgery for colonic diverticular disease.
Article in United European gastroenterology journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 12 citations in OpenAlex.
- Bowel movement alterations predict the severity of diverticular disease and the risk of acute diverticulitis: a prospective, international study.Intestinal research · 2025Article
- Clinical features and risk factors for appendiceal diverticulitis: a comparative study with acute appendicitis.Surgery today · 2024Article
- State-of-the-art surgery for sigmoid diverticulitis.Langenbeck's archives of surgery · 2022Article
- Ultrastructural changes of the human enteric nervous system and interstitial cells of Cajal in diverticular disease.Histology and histopathology · 2020Article
- Italian nationwide survey of pharmacologic treatments in diverticular disease: Results from the REMAD registry.United European gastroenterology journal · 2019Article
- Myotonic dystrophy type 1 and pseudo-obstruction in a child with smooth muscle α-actin deficiency and eosinophilic myenteric plexitis.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Article
- Identification of a rare LAMB4 variant associated with familial diverticulitis through exome sequencing.Human molecular genetics · 2017Article
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Authors and funding
14 authors at 7 institutions in 3 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundDiverticular disease of the colon is frequent in clinical practice, and a large number of patients each year undergo surgical procedures worldwide for their symptoms. Thus, there is a need for better knowledge of the basic pathophysiologic mechanisms of this disease entity.
objectivesBecause patients with colonic diverticular disease have been shown to display abnormalities of the enteric nervous system, we assessed the frequency of myenteric plexitis (i.e. the infiltration of myenteric ganglions by inflammatory cells) in patients undergoing surgery for this condition.
methodsWe analyzed archival resection samples from the proximal resection margins of 165 patients undergoing left hemicolectomy (60 emergency and 105 elective surgeries) for colonic diverticulitis, by histology and immunochemistry.
resultsOverall, plexitis was present in almost 40% of patients. It was subdivided into an eosinophilic (48%) and a lymphocytic (52%) subtype. Plexitis was more frequent in younger patients; and it was more frequent in those undergoing emergency surgery (50%), compared to elective (28%) surgery (p = 0.007). All the severe cases of plexitis displayed the lymphocytic subtype.
conclusionsIn conclusion, myenteric plexitis is frequent in patients with colonic diverticular disease needing surgery, and it might be implicated in the pathogenesis of the disease.
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