Evidence map›Paper›PMID 26668630›Full record

ArticleExperimental and therapeutic medicine2015

Antiproliferative effect and characterization of a novel antifungal peptide derived from human Chromogranin A.

Rui-Fang Li, Ya-Li Lu, Yan-Bo Lu, Hui-Ru Zhang, Liang Huang, Yanli Yin, Lin Zhang, Shuai Liu, Zhifang Lu, Yanan Sun

Open access · diamondAbstract read
In one paragraph

Article in Experimental and therapeutic medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 23 citations in OpenAlex.

  1. Review
  2. Antimicrobial Peptides with Anti-International journal of molecular sciences · 2022
    Review
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. The Antifungal Peptide MCh-AMP1 Derived FromFrontiers in microbiology · 2019
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rui-Fang LiCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Ya-Li LuCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Yan-Bo LuCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Hui-Ru ZhangCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Liang HuangCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Yanli YinCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Lin ZhangCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Shuai LiuCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Zhifang LuCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Yanan SunCollege of Biological Engineering, Henan University of Technology, Zhengzhou, Henan 450001, P.R. China.
Henan University of Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

CGA-N46 is a novel antifungal peptide derived from the N-terminus of human Chromogranin A, corresponding to the 31st to 76th amino acids. Further research on its activities and characteristics may be helpful for the application of CGA-N46 in medical or other situations. In the present study, the antifungal spectrum and physicochemical characteristics of CGA-N46 were investigated using an antifungal assay, its antiproliferative effects on cancer and normal cells were assessed using MTT assay and its combinatorial effect with other antibiotics was analyzed using checkerboard analysis. The results showed that CGA-N46 exhibited antifungal activity against the tested

Indexed as

additive combinationantifungal peptideanti-proliferationCGA-N46Chromogranin Aphysicochemical stability

Identifiers

PMID26668630
PMCPMC4665259
OpenAlexW1929262151

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.