Evidence map›Paper›PMID 26668504›Full record

ArticleWorld journal of gastroenterology2015

Biliary tract external drainage protects against intestinal barrier injury in hemorrhagic shock rats.

Lu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact, top 90% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. Intensive management of severe acute pancreatitis.Annals of translational medicine · 2019
    Review
  4. Bletilla striata polysaccharides ameliorates lipopolysaccharide-induced injury in intestinal epithelial cells.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Lu WangLu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao, Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Bing ZhaoLu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao, Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ying ChenLu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao, Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Li MaLu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao, Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Er-Zhen ChenLu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao, Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
En-Qiang MaoLu Wang, Bing Zhao, Ying Chen, Li Ma, Er-Zhen Chen, En-Qiang Mao, Department of Emergency Intensive Care Unit, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
Ruijin Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo investigate the effects of biliary tract external drainage (BTED) on intestinal barrier injury in rats with hemorrhagic shock (HS).

methodsBTED was performed via cannula insertion into the bile duct of rats. HS was induced by drawing blood from the femoral artery at a rate of 1 mL/min until a mean arterial pressure (MAP) of 40 ± 5 mmHg was achieved. That MAP was maintained for 60 min. A total of 99 Sprague-Dawley rats were randomized into a sham group, an HS group and an HS + BTED group. Nine rats in the sham group were sacrificed 0.5 h after surgery. Nine rats in each of the HS and HS + BTED groups were sacrificed 0.5 h, 1 h, 2 h, 4 h and 6 h after resuscitation. Plasma tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and lipopolysaccharide (LPS) levels were analyzed using enzyme-linked immunosorbent assay. Plasma D-lactate levels were analyzed using colorimetry. The expression levels of occludin and claudin-1 in the ileum were analyzed using Western blot and immunohistochemistry. Histology of the ileum was evaluated by hematoxylin and eosin staining.

resultsPlasma TNF-α levels in the HS + BTED group decreased significantly compared with the HS group at 1 h and 6 h after resuscitation (P < 0.05). Plasma IL-6 levels in the HS + BTED group decreased significantly compared with the HS group at 0.5 h, 1 h and 2 h after resuscitation (P < 0.05). Plasma D-lactate and LPS levels in the HS + BTED group decreased significantly compared with the HS group at 6 h after resuscitation (P < 0.05). The expression levels of occludin in the HS + BTED group increased significantly compared with the HS group at 4 h and 6 h after resuscitation (P < 0.05). The expression levels of claudin-1 in the HS + BTED group increased significantly compared with the HS group at 6 h after resuscitation (P < 0.05). Phenomena of putrescence and desquamation of epithelial cells in the ileal mucosa were attenuated in the HS + BTED group. Ileal histopathologic scores in the HS + BTED group decreased significantly compared with the HS group at 2 h, 4 h and 6 h after resuscitation (P < 0.05).

conclusionBTED protects against intestinal barrier injury in HS rats.

Indexed as

AnimalsBiliary Tract Surgical ProceduresBiomarkersBlotting, WesternClaudin-1Disease Models, AnimalDrainageIleumImmunohistochemistryInflammation MediatorsInterleukin-6Lactic AcidLipopolysaccharidesMaleOccludinRats, Sprague-DawleyBiomarkersClaudin-1Cldn1 protein, ratInflammation MediatorsInterleukin-6Lactic AcidLipopolysaccharidesOccludinOcln protein, ratTumor Necrosis Factor-alphaBiliary tract external drainageClaudin-1D-lactateHemorrhagic shockOccludin

Identifiers

PMID26668504
PMCPMC4671035
OpenAlexW2198730000

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.