Evidence map›Paper›PMID 26668401›Full record

ArticleJournal of physics D: Applied physics2015

Singular Value Decomposition of Optically-Mapped Cardiac Rotors and Fibrillatory Activity.

A Rabinovitch, Y Biton, D Braunstein, M Friedman, I Aviram, S Yandrapalli, S V Pandit, O Berenfeld

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of physics D: Applied physics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

A RabinovitchPhysics Department, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
Y BitonPhysics Department, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
D BraunsteinPhysics Department. Sami Shamoon College of Engineering, Beer-Sheva, Israel.
M FriedmanDepartment of Information Systems Engineering, Ben-Gurion University, Beer Sheva 84105, Israel.
I AviramPhysics Department, Ben-Gurion University of the Negev, Beer-Sheva, 84105, Israel.
S YandrapalliCenter for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109, USA.
S V PanditCenter for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109, USA.
O BerenfeldCenter for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109, USA.

Funding

THREE DIMENSIONAL VORTEX LIKE REENTRY IN CORONARY PERFUSED VENTRICULAR WALLP01HL039707 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI JALIFE, JOSE S · 1990 to 2010
$19.0M
P3: Biophysical Mechanisms in two Arhythmogenic DiseasesP01HL087226 · NHLBI · UPSTATE MEDICAL UNIVERSITY · PI JALIFE, JOSE S · 2007 to 2012
$10.3M
Mapping Electrical Activation in Atrial FibrillationR01HL118304 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BERENFELD, OMER · 2013 to 2016
$1.5M
NHLBI NIH HHS P01 HL039707NHLBI NIH HHS P01 HL087226NHLBI NIH HHS R01 HL118304
6 · The paper itself

Abstract

Our progress of understanding how cellular and structural factors contribute to the arrhythmia is hampered in part because of controversies whether a fibrillating heart is driven by a single, several, or multiple number of sources, and whether they are focal or reentrant, and how to localize them. Here we demonstrate how a novel usage of the neutral singular value decomposition (SVD) method enables the extraction of the governing spatial and temporal modes of excitation from a rotor and fibrillatory waves. Those modes highlight patterns and regions of organization in the midst of the otherwise seemingly-randomly propagating excitation waves. We apply the method to experimental models of cardiac fibrillation in rabbit hearts. We show that the SVD analysis is able to enhance the classification of the heart electrical patterns into regions harboring drivers in the form of fast reentrant activity and other regions of by-standing activity. This enhancement is accomplished without any prior assumptions regarding the spatial, temporal or spectral properties of those drivers. The analysis corroborates that the dominant mode has the highest activation rate and further reveals a new feature: A transfer of modes from the driving to the passive regions resulting in a partial reaction of the passive region to the driving region.

Indexed as

dominant frequencyphase analysisrotorsSingular Value Decompositionventricular fibrillation

Identifiers

PMID26668401
PMCPMC4676718

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.