ArticleProceedings of the National Academy of Sciences of the United States of America2015
Global divergence of the human follicle mite Demodex folliculorum: Persistent associations between host ancestry and mite lineages.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- First Detection of Human- and Dog-AssociatedPathogens (Basel, Switzerland) · 2026Article
- Aesthetic medicine treatments in reducing the effects of chronic demodicosis.Parasitology research · 2025Article
- Article
- Demodex and the eye - A review.Indian journal of ophthalmology · 2025Review
- Reducing ocularFrontiers in allergy · 2025Article
- Epidemiological survey of two morphotypes ofParasite epidemiology and control · 2024Article
- Predicting host range expansion in parasitic mites using a global mammalian-acarine dataset.Nature communications · 2024Article
- A new species ofInternational journal for parasitology. Parasites and wildlife · 2024Article
- Natural Products as Mite Control Agents in Animals: A Review.Molecules (Basel, Switzerland) · 2023Review
- Article
- The Acari Hypothesis, III: Atopic Dermatitis.Pathogens (Basel, Switzerland) · 2022Article
- Human follicular mites: Ectoparasites becoming symbionts.Molecular biology and evolution · 2022Article
- Treatment of ocularAmerican journal of ophthalmology case reports · 2022Article
- Phylogeography of the parasitic mite Laelaps agilis in Western Palearctic shows lineages lacking host specificity but possessing different demographic histories.BMC zoology · 2022Article
- Article
- Shared Makeup Cosmetics as a Route of Demodex folliculorum Infections.Acta parasitologica · 2021Article
- Nematode epibionts on skin of the Florida manatee, Trichechus manatus latirostris.Scientific reports · 2021Article
- The Pathogenic Role of Demodex Mites in Rosacea: A Potential Therapeutic Target Already in Erythematotelangiectatic Rosacea?Dermatology and therapy · 2020Review
- Cox1 barcoding versus multilocus species delimitation: validation of two mite species with contrasting effective population sizes.Parasites & vectors · 2019Article
- Investigating species boundaries using DNA and morphology in the mite Tyrophagus curvipenis (Acari: Acaridae), an emerging invasive pest, with a molecular phylogeny of the genus Tyrophagus.Experimental & applied acarology · 2018Article
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Authors and funding
9 authors at 6 institutions in 3 countries.
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Abstract
Microscopic mites of the genus Demodex live within the hair follicles of mammals and are ubiquitous symbionts of humans, but little molecular work has been done to understand their genetic diversity or transmission. Here we sampled mite DNA from 70 human hosts of diverse geographic ancestries and analyzed 241 sequences from the mitochondrial genome of the species Demodex folliculorum. Phylogenetic analyses recovered multiple deep lineages including a globally distributed lineage common among hosts of European ancestry and three lineages that primarily include hosts of Asian, African, and Latin American ancestry. To a great extent, the ancestral geography of hosts predicted the lineages of mites found on them; 27% of the total molecular variance segregated according to the regional ancestries of hosts. We found that D. folliculorum populations are stable on an individual over the course of years and that some Asian and African American hosts maintain specific mite lineages over the course of years or generations outside their geographic region of birth or ancestry. D. folliculorum haplotypes were much more likely to be shared within families and between spouses than between unrelated individuals, indicating that transmission requires close contact. Dating analyses indicated that D. folliculorum origins may predate modern humans. Overall, D. folliculorum evolution reflects ancient human population divergences, is consistent with an out-of-Africa dispersal hypothesis, and presents an excellent model system for further understanding the history of human movement.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.