ArticleProceedings of the National Academy of Sciences of the United States of America2015
Origin and diversification of wings: Insights from a neopteran insect.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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36 citing papers in PubMed, 82 citations in OpenAlex.
- Deep learning reveals ecological decoupling and rate heterogeneity in Hymenoptera wing evolution.Science advances · 2026Article
- Rewiring of two conserved signalling hubs into one axis underlies convergent female-specific wing regression in insects.Nature ecology & evolution · 2026Article
- Evolution and Development of Insect Metamorphosis: A Case of Genetic Accommodation?Results and problems in cell differentiation · 2026Review
- Evolutionary constraints shape the diversity of microinsects' wing morphology.Proceedings. Biological sciences · 2025Article
- Insect Flight: State of the Field and Future Directions.Integrative and comparative biology · 2024Article
- Contrasting nidification behaviors facilitate diversification and colonization of the Music frogs under a changing paleoclimate.Communications biology · 2024Article
- Dual Functions of labial Resolve the Hox Logic of Chelicerate Head Segments.Molecular biology and evolution · 2023Article
- Molecular and Developmental Signatures of Genital Size Macro-Evolution in Bugs.Molecular biology and evolution · 2022Article
- Flight or protection: the genesProceedings. Biological sciences · 2022Article
- A hemimetabolous wing development suggests the wing origin from lateral tergum of a wingless ancestor.Nature communications · 2022Article
- ThemicroPublication biology · 2022Article
- Out from under the wing: reconceptualizing the insect wing gene regulatory network as a versatile, general module for body-wall lobes in arthropods.Proceedings. Biological sciences · 2021Article
- Wing serial homologues and the diversification of insect outgrowths: insights from the pupae of scarab beetles.Proceedings. Biological sciences · 2021Article
- Anterior Hox Genes and the Process of Cephalization.Frontiers in cell and developmental biology · 2021Review
- Two sets of candidate crustacean wing homologues and their implication for the origin of insect wings.Nature ecology & evolution · 2020Article
- Knockout of crustacean leg patterning genes suggests that insect wings and body walls evolved from ancient leg segments.Nature ecology & evolution · 2020Article
- Article
- A hemipteran insect reveals new genetic mechanisms and evolutionary insights into tracheal system development.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Co-option of wing-patterning genes underlies the evolution of the treehopper helmet.Nature ecology & evolution · 2020Article
- Gene content evolution in the arthropods.Genome biology · 2020Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Winged insects underwent an unparalleled evolutionary radiation, but mechanisms underlying the origin and diversification of wings in basal insects are sparsely known compared with more derived holometabolous insects. In the neopteran species Oncopeltus fasciatus, we manipulated wing specification genes and used RNA-seq to obtain both functional and genomic perspectives. Combined with previous studies, our results suggest the following key steps in wing origin and diversification. First, a set of dorsally derived outgrowths evolved along a number of body segments including the first thoracic segment (T1). Homeotic genes were subsequently co-opted to suppress growth of some dorsal flaps in the thorax and abdomen. In T1 this suppression was accomplished by Sex combs reduced, that when experimentally removed, results in an ectopic T1 flap similar to prothoracic winglets present in fossil hemipteroids and other early insects. Global gene-expression differences in ectopic T1 vs. T2/T3 wings suggest that the transition from flaps to wings required ventrally originating cells, homologous with those in ancestral arthropod gill flaps/epipods, to migrate dorsally and fuse with the dorsal flap tissue thereby bringing new functional gene networks; these presumably enabled the T2/T3 wing's increased size and functionality. Third, "fused" wings became both the wing blade and surrounding regions of the dorsal thorax cuticle, providing tissue for subsequent modifications including wing folding and the fit of folded wings. Finally, Ultrabithorax was co-opted to uncouple the morphology of T2 and T3 wings and to act as a general modifier of hindwings, which in turn governed the subsequent diversification of lineage-specific wing forms.
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