ArticleProceedings of the National Academy of Sciences of the United States of America2015
Hyperpolarization-activated, cyclic nucleotide-gated cation channels in Aplysia: Contribution to classical conditioning.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- SPI1 exacerbates neurogenic bladder dysfunction by enhancing NRSF-mediated suppression of HCN1 and inducing endoplasmic reticulum stress.In vitro cellular & developmental biology. Animal · 2026Article
- Inhibition of the voltage-gated potassium channel Kv1.5 by hydrogen sulfide attenuates remodeling through S-nitrosylation-mediated signaling.Communications biology · 2023Article
- A review of the circuit-level and cellular mechanisms contributing to locomotor acceleration in the marine molluskFrontiers in neuroscience · 2022Review
- Rational ion transport management mediated through membrane structures.Exploration (Beijing, China) · 2021Review
- Comparison of the ionic currents modulated during activity-dependent and normal presynaptic facilitation.Learning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- The contributions and mechanisms of changes in excitability during simple forms of learning in Aplysia.Neurobiology of learning and memory · 2019Article
- Persistent effects of cyclic adenosine monophosphate are directly responsible for maintaining a neural network state.Scientific reports · 2019Article
- Hyperpolarization-Activated Cyclic Nucleotide-Gated Ion (HCN) Channels Regulate PC12 Cell Differentiation Toward Sympathetic Neuron.Frontiers in cellular neuroscience · 2019Article
- Intermediate-term memory inLearning & memory (Cold Spring Harbor, N.Y.) · 2018Article
- Decreased hyperpolarization-activated cyclic nucleotide-gated channels are involved in bladder dysfunction associated with spinal cord injury.International journal of molecular medicine · 2018Article
- Inhibition of GluR Current in Microvilli of Sensory Neurons via NaFrontiers in cellular neuroscience · 2018Article
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Authors and funding
7 authors at 4 institutions in 1 country.
Funding
Abstract
Hyperpolarization-activated, cyclic nucleotide-gated cation (HCN) channels are critical regulators of neuronal excitability, but less is known about their possible roles in synaptic plasticity and memory circuits. Here, we characterized the HCN gene organization, channel properties, distribution, and involvement in associative and nonassociative forms of learning in Aplysia californica. Aplysia has only one HCN gene, which codes for a channel that has many similarities to the mammalian HCN channel. The cloned acHCN gene was expressed in Xenopus oocytes, which displayed a hyperpolarization-induced inward current that was enhanced by cGMP as well as cAMP. Similarly to its homologs in other animals, acHCN is permeable to K(+) and Na(+) ions, and is selectively blocked by Cs(+) and ZD7288. We found that acHCN is predominantly expressed in inter- and motor neurons, including LFS siphon motor neurons, and therefore tested whether HCN channels are involved in simple forms of learning of the siphon-withdrawal reflex in a semiintact preparation. ZD7288 (100 μM) significantly reduced an associative form of learning (classical conditioning) but had no effect on two nonassociative forms of learning (intermediate-term sensitization and unpaired training) or baseline responses. The HCN current is enhanced by nitric oxide (NO), which may explain the postsynaptic role of NO during conditioning. HCN current in turn enhances the NMDA-like current in the motor neurons, suggesting that HCN channels contribute to conditioning through this pathway.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.