ArticleThe Journal of cell biology2015
The microtubule catastrophe promoter Sentin delays stable kinetochore-microtubule attachment in oocytes.
Article in The Journal of cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation inMolecular biology of the cell · 2024Article
- Meiosis-specific functions of kinetochore protein SPC105R required for chromosome segregation inbioRxiv : the preprint server for biology · 2024Article
- A dynamic population of prophase CENP-C is required for meiotic chromosome segregation.PLoS genetics · 2023Article
- Tau, XMAP215/Msps and Eb1 co-operate interdependently to regulate microtubule polymerisation and bundle formation in axons.PLoS genetics · 2021Article
- Borealin directs recruitment of the CPC to oocyte chromosomes and movement to the microtubules.The Journal of cell biology · 2021Article
- Spindle assembly and chromosome dynamics during oocyte meiosis.Current opinion in cell biology · 2019Review
- The molecular architecture of the meiotic spindle is remodeled during metaphase arrest in oocytes.The Journal of cell biology · 2019Article
- Live cell imaging of meiosis ineLife · 2019Article
- Sister centromere fusion during meiosis I depends on maintaining cohesins and destabilizing microtubule attachments.PLoS genetics · 2019Article
- A computational model of the early stages of acentriolar meiotic spindle assembly.Molecular biology of the cell · 2019Article
- Article
- Female Meiosis: Synapsis, Recombination, and Segregation inGenetics · 2018Review
- Combining microscopy and biochemistry to study meiotic spindle assembly in Drosophila oocytes.Methods in cell biology · 2018Article
- 14-3-3 regulation of Ncd reveals a new mechanism for targeting proteins to the spindle in oocytes.The Journal of cell biology · 2017Article
- Plk1 is essential for proper chromosome segregation during meiosis I/meiosis II transition in pig oocytes.Reproductive biology and endocrinology : RB&E · 2017Article
- The chromosomal basis of meiotic acentrosomal spindle assembly and function in oocytes.Chromosoma · 2017Review
- An unconventional interaction between Dis1/TOG and Mal3/EB1 in fission yeast promotes the fidelity of chromosome segregation.Journal of cell science · 2016Article
- Meiotic spindle assembly and chromosome segregation in oocytes.The Journal of cell biology · 2016Review
- Oocyte Maturation and Development.F1000Research · 2016Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
The critical step in meiosis is to attach homologous chromosomes to the opposite poles. In mouse oocytes, stable microtubule end-on attachments to kinetochores are not established until hours after spindle assembly, and phosphorylation of kinetochore proteins by Aurora B/C is responsible for the delay. Here we demonstrated that microtubule ends are actively prevented from stable attachment to kinetochores until well after spindle formation in Drosophila melanogaster oocytes. We identified the microtubule catastrophe-promoting complex Sentin-EB1 as a major factor responsible for this delay. Without this activity, microtubule ends precociously form robust attachments to kinetochores in oocytes, leading to a high proportion of homologous kinetochores stably attached to the same pole. Therefore, regulation of microtubule ends provides an alternative novel mechanism to delay stable kinetochore-microtubule attachment in oocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.