Evidence map›Paper›PMID 26668316›Full record

ArticleThe Journal of biological chemistry2016

Insulin Is Required to Maintain Albumin Expression by Inhibiting Forkhead Box O1 Protein.

Qing Chen, Mingjian Lu, Bobby R Monks, Morris J Birnbaum

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.1field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 46 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Review
  15. Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Qing ChenFrom the Institute for Diabetes, Obesity, and Metabolism, Department of Biochemistry and Biophysics, and Graduate Group of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and.
Mingjian LuFrom the Institute for Diabetes, Obesity, and Metabolism.
Bobby R MonksFrom the Institute for Diabetes, Obesity, and Metabolism.
Morris J BirnbaumFrom the Institute for Diabetes, Obesity, and Metabolism, Department of Biochemistry and Biophysics, and Graduate Group of Biochemistry and Molecular Biophysics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 and the Cardiovascular and Metabolic Disease Research Unit, Pfizer Inc., Cambridge, Massachusetts 02140 birnbaum@mail.med.upenn.edu.
Institute of Nutrition, Metabolism and Diabetes · CAInstitute of Molecular Biology and Biophysics · RUUniversity of Pennsylvania · US

Funding

THE ROLE OF THE AKT/PKB SIGNALING IN INSULIN ACTIONR01DK056886 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI BIRNBAUM, MORRIS J · 2000 to 2014
$5.3M
NIDDK NIH HHS R01 DK056886NIDDK NIH HHS R01 DK56886
6 · The paper itself

Abstract

Diabetes is accompanied by dysregulation of glucose, lipid, and protein metabolism. In recent years, much effort has been spent on understanding how insulin regulates glucose and lipid metabolism, whereas the effect of insulin on protein metabolism has received less attention. In diabetes, hepatic production of serum albumin decreases, and it has been long established that insulin positively controls albumin gene expression. In this study, we used a genetic approach in mice to identify the mechanism by which insulin regulates albumin gene transcription. Albumin expression was decreased significantly in livers with insulin signaling disrupted by ablation of the insulin receptor or Akt. Concomitant deletion of Forkhead Box O1 (Foxo1) in these livers rescued the decreased albumin secretion. Furthermore, activation of Foxo1 in the liver is sufficient to suppress albumin expression. These results suggest that Foxo1 acts as a repressor of albumin expression.

Indexed as

Gene Expression RegulationAlbuminsAnimalsBlood GlucoseCCAAT-Enhancer-Binding ProteinsCell NucleusDiabetes Mellitus, ExperimentalDiabetes Mellitus, Type 1Forkhead Box Protein O1Forkhead Transcription FactorsHepatocytesInsulinLiverMaleMiceProto-Oncogene Proteins c-aktAkt1 protein, mouseAlbuminsBlood GlucoseCCAAT-Enhancer-Binding ProteinsCEBPA protein, mouseForkhead Box Protein O1Forkhead Transcription FactorsFoxo1 protein, mouseInsulinProto-Oncogene Proteins c-aktRNA, MessengerStreptozocinalbuminFOXOinsulintranscriptiontranscription repressor

Identifiers

PMID26668316
PMCPMC4732219
OpenAlexW2257953339

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.