ArticleThe Journal of veterinary medical science2016
Histological and immunohistochemical studies on primary intracranial canine histiocytic sarcomas.
Article in The Journal of veterinary medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 37 citations in OpenAlex.
- Fibroblastic and myofibroblastic differentiation of cutaneous pleomorphic sarcomas in rabbits.The Journal of veterinary medical science · 2026Article
- Rodent monocyte-derived macrophages do not express CD163: Comparative analysis using macrophages from living boreoeutherians.Developmental dynamics : an official publication of the American Association of Anatomists · 2026Article
- Case report: Pulmonary non-Langerhans cell histiocytosis in a dog with acute interstitial granulomatous pneumonia.Frontiers in veterinary science · 2025Article
- Histiocytic sarcoma with spinal necrosis in a dog with progressing non-ambulatory tetraparesis.Open veterinary journal · 2023Article
- Comparison of the Clinical Characteristics of Histiocytic Sarcoma in Bernese Mountain Dogs and Flat-Coated Retrievers.Veterinary sciences · 2022Article
- RNA in situ hybridisation as a molecular diagnostic technique targeting IBA-1 and CD204 in canine histiocytic sarcoma.Veterinary medicine and science · 2022Article
- Successful use of prednisolone and radiation therapy in a dog with intracranial histiocytic sarcoma.The Journal of veterinary medical science · 2021Article
- Immunohistochemical Characterization of Tumor-Associated Macrophages in Canine Lymphomas.Animals : an open access journal from MDPI · 2021Article
- Clinical, histopathological, and immunohistochemical studies of histiocytic sarcoma in four-toed hedgehogs (Atelerix albiventris): A retrospective study.The Journal of veterinary medical science · 2021Review
- Recessive missense LAMP3 variant associated with defect in lamellar body biogenesis and fatal neonatal interstitial lung disease in dogs.PLoS genetics · 2020Article
- Clinicopathological characteristics of histiocytic sarcoma affecting the central nervous system in dogs.Journal of veterinary internal medicine · 2020Article
- A retrospective survey on canine intracranial tumors between 2007 and 2017.The Journal of veterinary medical science · 2020Article
- Malignant rhabdoid tumor of the musk gland and systemic T-cell lymphoma in a masked palm civet (Paguma larvata).The Journal of veterinary medical science · 2019Article
- Vascular endothelial growth factor suppresses dendritic cells function of human prostate cancer.OncoTargets and therapy · 2018Article
- Disseminated histiocytic sarcoma with hemophagocytosis in a rabbit.The Journal of veterinary medical science · 2017Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Histiocytic sarcoma is a progressive and fatal malignant neoplasm that mainly occurs in middle- to old-aged dogs. This study describes clinicopathological, histological and immunohistochemical characteristics of intracranial histiocytic sarcomas in 23 dogs. Magnetic resonance imaging and/or computed tomography of the brains revealed that the tumors mainly located in the cerebrum, particularly the frontal lobe. Seizure was a predominant clinical sign in most of the cases. Histologically, the tumor cells were morphologically classified into round/polygonal- and spindle-shaped cell types. There was a significant association between tumor cell types and hemophagocytic activity (P<0.05). However, there was no significant difference in other clinicopathological parameters and mitotic index between the 2 types. Immunohistochemically, tumor cells were strongly positive for HLA-DR, Iba-1 and CD204 in all the 23 cases, for iNOS in 20, for CD163 in 17, for CD208 (DC-LAMP) in 9, for lysozyme in 8 and for S100 in 5 cases. In addition, the Ki67-proliferative index showed range of 0.50-64.33% (Average 26.60 ± 3.81%). These observations suggest that canine primary intracranial histiocytic sarcomas tend to exhibit both dendritic cell and macrophage phenotypes of histiocytic differentiation.
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