ArticleChinese medical journal2015
Relationship Between Serum Zinc Level and Microvascular Complications in Patients with Type 2 Diabetes.
Article in Chinese medical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 61 citations in OpenAlex.
- Diet and ideal food pyramid to prevent or support the treatment of diabetic retinopathy, age-related macular degeneration, and cataracts.Frontiers in medicine · 2023Pooled it
- Associations of serum low-density lipoprotein and systolic blood pressure levels with type 2 diabetic patients with and without peripheral neuropathy: systemic review, meta-analysis and meta-regression analysis of observational studies.BMC endocrine disorders · 2019Pooled it
- Zinc Status and Risk of Cardiovascular Diseases and Type 2 Diabetes Mellitus-A Systematic Review of Prospective Cohort Studies.Nutrients · 2016Pooled it
- Associations between Serum Zinc Levels and the Presence of Distal Symmetric Polyneuropathy in Patients with Type 2 Diabetes Mellitus.Endocrinology, diabetes & metabolism · 2026Article
- Rethinking Zinc Requirements in Diabetes Mellitus: Comprehensive Review of Experimental and Clinical Studies Evidence.Biological trace element research · 2026Review
- Article
- [Diabetic retinopathy and risk modification through diet and dietary supplements].Die Ophthalmologie · 2025Review
- Novel impact of metal ion-induced cell death on diabetic cardiomyopathy pathogenesis and therapy.Apoptosis : an international journal on programmed cell death · 2025Review
- Association between dietary multi-metal intake and the risk of diabetic retinopathy: a population-based study.Frontiers in nutrition · 2025Article
- Effects of dietary oxidative balance score on diabetic nephropathy and renal function: insights from retrospective and cross-sectional studies.Frontiers in nutrition · 2025Article
- The Impact of Zinc Supplementation on Hyperglycemia and Complications of Type 2 Diabetes Mellitus.Cureus · 2024Article
- A New Concept in Antidiabetic Therapeutics: A Concerted Removal of Labile Iron and Intracellular Deposition of Zinc.Diabetes & metabolism journal · 2024Article
- A Mediterranean Diet May Be Protective in the Development of Diabetic Retinopathy.International journal of molecular sciences · 2023Review
- Antioxidant Nutraceutical Strategies in the Prevention of Oxidative Stress Related Eye Diseases.Nutrients · 2023Review
- Nutraceutical Prevention of Diabetic Complications-Focus on Dicarbonyl and Oxidative Stress.Current issues in molecular biology · 2022Review
- Influence of zinc levels and Nrf2 expression in the clinical and pathological changes in patients with diabetic nephropathy.Nutrition & diabetes · 2022Article
- Serum levels of copper and zinc in diabetic retinopathy: Potential new therapeutic targets (Review).Experimental and therapeutic medicine · 2022Review
- Role of Zinc in Diabetic Kidney Disease.Nutrients · 2022Review
- The Effect of Diet and Lifestyle on the Course of Diabetic Retinopathy-A Review of the Literature.Nutrients · 2022Review
- Relationships of the Trace Elements Zinc and Magnesium With Diabetic Nephropathy-Associated Renal Functional Damage in Patients With Type 2 Diabetes Mellitus.Frontiers in medicine · 2021Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPrevious studies suggested that zinc level was related to a certain diabetic microvascular complication. However, the relationship between zinc level and all the microvascular complications in type 2 diabetic patients remains unknown. The purpose of this study was to analyze the relationship between zinc level and each diabetic microvascular complication and identify the features related to low serum zinc level.
methodsWe included the hospitalized patients with type 2 diabetes (T2D) at our department from May 30, 2013 to March 31, 2014. We initially compared the serum zinc levels between patients with specific microvascular complications and those without. We then analyzed the association between zinc level and each microvascular complication. Furthermore, we identified the unique features of patients with high and low serum zinc levels and analyzed the risk factors related to low zinc level.
resultsThe 412 patients included 271 with microvascular complications and 141 without any microvascular complications. Serum zinc level was significantly lower in patients with diabetic retinopathy (P < 0.001), diabetic nephropathy (DN, P < 0.001), or diabetic peripheral neuropathy (P = 0.002) compared with patients without that specific complication. Lower zinc level was an independent risk factor for DN (odds ratio = 0.869, 95% confidence interval = 0.765-0.987, P < 0.05). The subjects with lower serum zinc level had manifested a longer duration of diabetes, higher level of hemoglobin A1c, higher prevalence of hypertension and microvascular complications, and lower fasting and 2-h C-peptide levels.
conclusionsLower serum zinc level in T2D patients was related to higher prevalence of diabetic microvascular complications, and represented as an independent risk factor for DN. Patients with lower zinc level were more likely to have a longer duration of diabetes, poorer glucose control, and worse β-cell function.
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