ArticleClinical journal of the American Society of Nephrology : CJASN2016
Association of APOL1 Genotype with Renal Histology among Black HIV-Positive Patients Undergoing Kidney Biopsy.
Article in Clinical journal of the American Society of Nephrology : CJASN, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Apolipoprotein L1 gene variants and kidney disease in patients with HIV: a systematic review and meta-analysis.Journal of nephrology · 2023Pooled it
- Kidney disease in the setting of HIV infection: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference.Kidney international · 2018Guideline
- Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral-treated human immunodeficiency virus infection.Internal medicine journal · 2026Article
- Article
- The changing landscape of HIV-associated kidney disease.Nature reviews. Nephrology · 2024Review
- Apolipoprotein L1 and mechanisms of kidney disease susceptibility.Current opinion in nephrology and hypertension · 2021Review
- Pharmacotherapeutic options for kidney disease in HIV positive patients.Expert opinion on pharmacotherapy · 2021Review
- Observational
- APOL1 Genetic Testing in Living Kidney Transplant Donors.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2019Review
- Kidney Disease in HIV Infection.Journal of clinical medicine · 2019Review
- Pharmacotherapy and treatment options for HIV-associated nephropathy.Expert opinion on pharmacotherapy · 2018Review
- HIV-Associated Nephropathy in Africa: Pathology, Clinical Presentation and Strategy for Prevention.Journal of clinical medicine research · 2018Review
- Association BetweenJournal of the American Heart Association · 2017Article
- APOL1 Renal Risk Variants: Fertile Soil for HIV-Associated Nephropathy.Seminars in nephrology · 2017Review
- The analysis of APOL1 genetic variation and haplotype diversity provided by 1000 Genomes project.BMC nephrology · 2017Article
- Strict blood pressure control associates with decreased mortality risk by APOL1 genotype.Kidney international · 2017Article
- HIV-Associated Nephropathy in 2022.Glomerular diseasesReview
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Authors and funding
12 authors.
Funding
Abstract
BACKGROUND AND
objectivesPrior studies have shown that the APOL1 risk alleles are associated with a greater risk of HIV-associated nephropathy and FSGS among blacks who are HIV positive. We sought to determine whether the APOL1 high-risk genotype incrementally improved the prediction of these underlying lesions beyond conventional clinical factors. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: In a cross-sectional study, we analyzed data from 203 blacks who are HIV positive, underwent kidney biopsies between 1996 and 2011, and were genotyped for the APOL1 G1 and G2 alleles. Predictive logistic regression models with conventional clinical factors were compared with those that also included APOL1 genotype using receiver-operating curves and bootstrapping analyses with crossvalidation.
resultsThe addition of APOL1 genotype to HIV-related risk factors for kidney disease in a predictive model improved the prediction of non-HIV-associated nephropathy FSGS, specifically, increasing the c statistic from 0.65 to 0.74 (P=0.04). Although two risk alleles were significantly associated with higher odds of HIV-associated nephropathy, APOL1 genotype did not add incrementally to the prediction of this specific histopathology.
conclusionsAPOL1 genotype may provide additional diagnostic information to traditional clinical variables in predicting underlying FSGS spectrum lesions in blacks who are HIV positive. In contrast, although APOL1 risk genotype predicts HIV-associated nephropathy, it lacked a high c statistic sufficient for discrimination to eliminate the role of kidney biopsy in the clinical care of blacks who are HIV positive with nephrotic proteinuria or unexplained kidney disease.
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