Trial reportSocial cognitive and affective neuroscience2016
Interindividual differences in stress sensitivity: basal and stress-induced cortisol levels differentially predict neural vigilance processing under stress.
Trial report in Social cognitive and affective neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 99 citations in OpenAlex.
- Functional MRI Techniques Suggesting that the Stress System Interacts with Three Large Scale Core Brain Networks to Help Coordinate the Adaptive Response: A Systematic Review.Current neuropharmacology · 2024Pooled it
- Associations between brain activity and endogenous and exogenous cortisol - A systematic review.Psychoneuroendocrinology · 2020Pooled it
- Effects of Brief Breathwork Under a State of Cognitive Fatigue on Subjective Well-Being and Diaphragm Function: A Randomized Crossover Design.Stress and health : journal of the International Society for the Investigation of Stress · 2026Trial
- Altered relationship between cortisol response to social stress and mediotemporal function during fear processing in people at clinical high risk for psychosis: a preliminary report.European archives of psychiatry and clinical neuroscience · 2022Trial
- Effects of Maternal and Cumulative Stress on Immune Phenotype and Stress Reactivity in Sows Later in Life.Animals : an open access journal from MDPI · 2026Article
- Sleep-anxiety symptom networks and subgroup characterization in nasopharyngeal carcinoma patients undergoing chemoradiotherapy: A latent profile and network analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Phenomenon of hypocortisolism in individuals with obesity.Comprehensive psychoneuroendocrinology · 2025Article
- Psychosocial stressors and cognitive function: An analysis using data from the English longitudinal study of ageing.The journal of prevention of Alzheimer's disease · 2025Article
- Adding to the burden: the tendency to resonate with others' stress is linked to higher PTSD symptom severity in individuals with war-related trauma.Translational psychiatry · 2025Article
- Burnout and the Brain-A Mechanistic Review of Magnetic Resonance Imaging (MRI) Studies.International journal of molecular sciences · 2025Review
- The heterogeneity in psychological distress among undergraduate nursing students: a latent profile analysis.BMC nursing · 2025Article
- Personality and Its Influence on Pain Sensitivity Based on Different Hormonal Responses to Individual vs. Group Exercise Styles.Life (Basel, Switzerland) · 2025Article
- Exposure to diesel-related particulate matter, cortisol stress responsivity, and depressive symptoms in adolescents.Psychoneuroendocrinology · 2025Article
- Heightened lateral habenula activity during stress produces brainwide and behavioral substrates of susceptibility.Neuron · 2024Article
- Interpersonal Factors and Resilience Mediate the Association Between Work-Related Stress in Response to a Viral Epidemic and Depression Among Healthcare Workers in the COVID-19 Pandemic.Psychiatry investigation · 2024Article
- The impact of mental health conditions on clinical and functional outcomes after shoulder arthroplasty: a systematic review.JSES reviews, reports, and techniques · 2024Review
- Relationship between heart rate variability and differential patterns of cortisol response to acute stressors in mid-life adults: A data-driven investigation.Stress and health : journal of the International Society for the Investigation of Stress · 2024Article
- Inter- and transgenerational heritability of preconception chronic stress or alcohol exposure: Translational outcomes in brain and behavior.Neurobiology of stress · 2024Article
- Emotional labor as emotion regulation investigated with ecological momentary assessment - a scoping review.BMC psychology · 2024Article
- Adolescent stress accelerates postpartum novelty recognition impairment in 5xFAD mice.Frontiers in neuroscience · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stress exposure is known to precipitate psychological disorders. However, large differences exist in how individuals respond to stressful situations. A major marker for stress sensitivity is hypothalamus-pituitary-adrenal (HPA)-axis function. Here, we studied how interindividual variance in both basal cortisol levels and stress-induced cortisol responses predicts differences in neural vigilance processing during stress exposure. Implementing a randomized, counterbalanced, crossover design, 120 healthy male participants were exposed to a stress-induction and control procedure, followed by an emotional perception task (viewing fearful and happy faces) during fMRI scanning. Stress sensitivity was assessed using physiological (salivary cortisol levels) and psychological measures (trait questionnaires). High stress-induced cortisol responses were associated with increased stress sensitivity as assessed by psychological questionnaires, a stronger stress-induced increase in medial temporal activity and greater differential amygdala responses to fearful as opposed to happy faces under control conditions. In contrast, high basal cortisol levels were related to relative stress resilience as reflected by higher extraversion scores, a lower stress-induced increase in amygdala activity and enhanced differential processing of fearful compared with happy faces under stress. These findings seem to reflect a critical role for HPA-axis signaling in stress coping; higher basal levels indicate stress resilience, whereas higher cortisol responsivity to stress might facilitate recovery in those individuals prone to react sensitively to stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.