Evidence map›Paper›PMID 26667956›Full record

ArticlePediatric cardiology2016

Early Ventricular Dysfunction After Anthracycline Chemotherapy in Children.

Hala Agha, Lobna Shalaby, Wael Attia, Gaser Abdelmohsen, Osama Abdel Aziz, Mohamed Youssef Abdel Rahman

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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  12. Cardiovascular Evaluation of Children With Malignancies.Current treatment options in cardiovascular medicine · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hala AghaPediatric Cardiology Division, Department of Pediatrics, Specialized Pediatric Hospital, Faculty of Medicine, Cairo University, Kasr Al Aini street, Cairo, 11562, Egypt. halaazza@gmail.com.
Lobna ShalabyDepartment of Pediatric Oncology, National Cancer Institute, Cairo University, Cairo, Egypt.
Wael AttiaPediatric Cardiology Division, Department of Pediatrics, Specialized Pediatric Hospital, Faculty of Medicine, Cairo University, Kasr Al Aini street, Cairo, 11562, Egypt.
Gaser AbdelmohsenPediatric Cardiology Division, Department of Pediatrics, Specialized Pediatric Hospital, Faculty of Medicine, Cairo University, Kasr Al Aini street, Cairo, 11562, Egypt.
Osama Abdel AzizPediatric Cardiology Division, Department of Pediatrics, Specialized Pediatric Hospital, Faculty of Medicine, Cairo University, Kasr Al Aini street, Cairo, 11562, Egypt.
Mohamed Youssef Abdel RahmanPediatric Cardiology Division, Department of Pediatrics, Specialized Pediatric Hospital, Faculty of Medicine, Cairo University, Kasr Al Aini street, Cairo, 11562, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The aim of this study was to determine the effect of induction dose of anthracycline chemotherapy on the biventricular function among children with acute hematological malignancies (AHM) using tissue Doppler imaging (TDI) and 2D speckle tracking echocardiography (2D-STE). Thirty pediatric patients with AHM and a mean age of 9.24 ± 4.14 years performed conventional echocardiography, TDI and 2D-STE. After induction chemotherapy, the RV showed mainly a diastolic alteration in its function manifested in significant reduction in the tricuspid TDI-derived E' and E'/A' ratio compared with the baseline (20.40 ± 3.81 vs. 17.47 ± 3.87 cm/s, p = 0.001, 1.29 ± 0.27 vs. 1.03 ± 0.37, p < 0.01, respectively), while the TDI-derived RV MPI and isovolumetric relaxation time of RV were significantly increased (0.32 ± 0.06 vs. 0.36 ± 0.08, p < 0.01, 24.73 ± 8.62 vs. 28.47 ± 11.51 ms, p < 0.05, respectively). The LV showed post-chemotherapy mainly an alteration in its longitudinal systolic function in the form of a reduction in MAPSE (13.61 ± 2.00 vs. 11.95 ± 1.75 mm; p < 0.001), TDI-derived systolic velocity of lateral mitral annulus (10.98 ± 2.34 vs. 10.03 ± 1.83 cm/s, p < 0.05), 2D-STE-derived global longitudinal strain (-21.58 ± 2.54 vs. -19.18 ± 3.59 %, p = 0.001) and 2D-STE-derived global longitudinal strain rate (-1.76 ± 0.22 vs. 1.55 ± 0.29 1/s, p < 0.05), with preservation of LV diastolic function when compared to baseline. TDI and 2D-STE could be used for early detection of anthracycline-induced cardiotoxicity in the pediatric age group. Early after induction chemotherapy, the RV develops mainly diastolic dysfunction, while the LV showed a relative longitudinal systolic impairment.

Indexed as

Echocardiography, Doppler, PulsedAdolescentAnthracyclinesChildChild, PreschoolCross-Sectional StudiesFemaleHematologic NeoplasmsHumansMaleMitral ValveMyocardial ContractionProspective StudiesVentricular DysfunctionVentricular Function, LeftAnthracyclines2D-STEAnthracyclineCardiotoxicityMPITDI

Identifiers

PMID26667956

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.