Evidence map›Paper›PMID 26667846›Full record

ArticleScientific reports2015

A Large-scale Survey of CRF55_01B from Men-Who-Have-Sex-with-Men in China: implying the Evolutionary History and Public Health Impact.

Xiaoxu Han, Yutaka Takebe, Weiqing Zhang, Minghui An, Bin Zhao, Qinghai Hu, Junjie Xu, Hao Wu, Jianjun Wu, Lin Lu and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Xiaoxu HanKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Yutaka TakebeKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Weiqing ZhangKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Minghui AnKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Bin ZhaoKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Qinghai HuKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Junjie XuKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Hao WuInfectious Diseases Department, Beijing Youan Hospital, Capital Medical University, Beijing, China.
Jianjun WuSexually transmitted Disease and AIDS Department, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
Lin LuYunnan Provincial Center for Disease Control and Prevention, Kunming, China.
Xi ChenAIDS/STIs Prevention and Control Department, Hunan Provincial Center for Disease Control and Prevention, Changsha, China.
Shu LiangSichuan provincial center for disease control and prevention, Chengdu, China.
Zhe WangHenan Provincial Center for Disease Control and Prevention, Zhengzhou, China.
Hongjing YanSexually Transmitted Disease and AIDS Prevention and Control Department, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Jihua FuSexually transmitted Disease and AIDS Department, Shandong Provincial Center for Disease Control and Prevention, Jinan, China.
Weiping CaiInfectious Disease Department, Guangzhou No. 8 Renmin Hospital, Guangzhou, China.
Minghua ZhuangSexually transmitted Disease and AIDS Department, Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China.
Christina LiaoKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.
Hong ShangKey Laboratory of AIDS Immunology of National Health and Family Planning Commission, Department of Laboratory Medicine, The First Affiliated Hospital of China Medical University, Shenyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The HIV-1 epidemic among men-who-have-sex-with-men (MSM) continues to expand in China, involving the co-circulation of several different lineages of HIV-1 strains, including subtype B and CRF01_AE. This expansion has created conditions that facilitate the generation of new recombinant strains. A molecular epidemiologic survey among MSM in 11 provinces/cities around China was conducted from 2008 to 2013. Based on pol nucleotide sequences, a total of 19 strains (1.95%) belonged to the CRF55_01B were identified from 975 MSM in 7 provinces, with the prevalence range from 1.5% to 12.5%. Near full length genome (NFLG) sequences from six epidemiologically-unlinked MSM were amplified for analyzing evolutionary history, an identical genome structure composed of CRF01_AE and subtype B with four unique recombination breakpoints in the pol region were identified. Bayesian molecular clock analyses for both CRF01_AE and B segments indicated that the estimated time of the most recent common ancestors of CRF55_01B was around the year 2000. Our study found CRF55_01B has spread throughout the most provinces with high HIV-1 prevalence and highlights the importance of continual surveillance of dynamic changes in HIV-1 strains, the emergence of new recombinants, and the need for implementing effective prevention measures specifically targeting the MSM population in China.

Indexed as

Surveys and QuestionnairesAdultAsian PeopleChinaCross-Sectional StudiesEvolution, MolecularGene FrequencyGenotypeGeographyHIV-1HIV InfectionsHomosexuality, MaleHost-Pathogen InteractionsHumansMalePhylogenypol Gene Products, Human Immunodeficiency Virus

Identifiers

PMID26667846
PMCPMC4678862

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.