ArticleGenome biology2015
Transcriptome-wide high-throughput deep m(6)A-seq reveals unique differential m(6)A methylation patterns between three organs in Arabidopsis thaliana.
Article in Genome biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers.
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109 citing papers in PubMed, 189 citations in OpenAlex.
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- B cell-specific METTL3 depletion exacerbates experimental autoimmune encephalomyelitis.Cellular and molecular life sciences : CMLS · 2026Article
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- Comprehensive genomic characterization and differential expression analysis of mBMC plant biology · 2025Article
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- A chromosome-anchored reference assembly for the gray snapper, Lutjanus griseus.Molecular biology reports · 2025Article
- N6-adenosine-methyltransferase MTA70-like participates antiviral responses inFrontiers in microbiology · 2025Article
- Exploring the potential ofCurrent research in toxicology · 2025Article
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- N6-methyladenosine RNA modification regulates photoperiod sensitivity in cotton.Plant physiology · 2024Article
- Variable calling of m6A and associated features in databases: a guide for end-users.Briefings in bioinformatics · 2024Review
- Quantitative profiling of mNature communications · 2024Article
- The m6A reader ECT1 drives mRNA sequestration to dampen salicylic acid-dependent stress responses in Arabidopsis.The Plant cell · 2024Article
- Identification ofFrontiers in plant science · 2024Article
- Detection, distribution, and functions of RNAFrontiers in plant science · 2024Review
- Systematic assessment of transcriptomic and metabolic reprogramming by blue light exposure coupled with aging.PNAS nexus · 2023Article
49 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundm(6)A is a ubiquitous RNA modification in eukaryotes. Transcriptome-wide m(6)A patterns in Arabidopsis have been assayed recently. However, differential m(6)A patterns between organs have not been well characterized.
resultsOver two-third of the transcripts in Arabidopsis are modified by m(6)A. In contrast to a recent observation of m(6)A enrichment in 5' mRNA, we find that m(6)A is distributed predominantly near stop codons. Interestingly, 85 % of the modified transcripts show high m(6)A methylation extent compared to their transcript level. The 290 highly methylated transcripts are mainly associated with transporters, stress responses, redox, regulation factors, and some non-coding RNAs. On average, the proportion of transcripts showing differential methylation between two plant organs is higher than that showing differential transcript levels. The transcripts with extensively higher m(6)A methylation in an organ are associated with the unique biological processes of this organ, suggesting that m(6)A may be another important contributor to organ differentiation in Arabidopsis. Highly expressed genes are relatively less methylated and vice versa, and different RNAs have distinct m(6)A patterns, which hint at mRNA fate. Intriguingly, most of the transposable element transcripts maintained a fragmented form with a relatively low transcript level and high m(6)A methylation in the cells.
conclusionsThis is the first study to comprehensively analyze m(6)A patterns in a variety of RNAs, the relationship between transcript level and m(6)A methylation extent, and differential m(6)A patterns across organs in Arabidopsis.
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