Trial reportScientific reports2015
Combined rTMS treatment targeting the Anterior Cingulate and the Temporal Cortex for the Treatment of Chronic Tinnitus.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.
- Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Guideline
- RTMS parameters in tinnitus trials: a systematic review.Scientific reports · 2019Pooled it
- A proof-of-concept study on the combination of repetitive transcranial magnetic stimulation and relaxation techniques in chronic tinnitus.Journal of neural transmission (Vienna, Austria : 1996) · 2016Trial
- Prolonged P3 latency predicts clinical response to repetitive transcranial magnetic stimulation in tinnitus.Clinical neurophysiology practice · 2026Article
- A Single Session of tDCS Stimulation Can Modulate an EEG Microstate Associated With Anxiety in Patients With Depression.Brain and behavior · 2025Article
- Auditory illusory models as proxies to investigate bottom-up and top-down neural networks of phantom perception.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Brain glucose metabolism on [18F]-FDG PET/CT: a dynamic biomarker predicting depression and anxiety in cancer patients.Frontiers in oncology · 2023Article
- Sequential Prefrontal and Temporoparietal Repetitive Transcranial Magnetic Stimulation (rTMS) for Treatment of Tinnitus With and Without Comorbid Depression: A Case Series and Systematic Review.Frontiers in neurology · 2022Article
- [Improving the role of rTMS and tDCS in the treatment of chronic tinnitus by combining other rehabilitation techniques].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2021Review
- Methodological Aspects of Randomized Controlled Trials for Tinnitus: A Systematic Review and How a Decision Support System Could Overcome Barriers.Journal of clinical medicine · 2021Review
- Characterizing off-target corticospinal responses to double-cone transcranial magnetic stimulation.Experimental brain research · 2021Article
- [The physiological function of cingulate cortex and its role in the mechanism of tinnitus].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2020Review
- Association of Central Noninvasive Brain Stimulation Interventions With Efficacy and Safety in Tinnitus Management: A Meta-analysis.JAMA otolaryngology-- head & neck surgery · 2020Article
- Resting motor threshold and magnetic field output of the figure-of-8 and the double-cone coil.Scientific reports · 2020Article
- rTMS-Induced Changes in Glutamatergic and Dopaminergic Systems: Relevance to Cocaine and Methamphetamine Use Disorders.Frontiers in neuroscience · 2020Review
- The Presence of Physical Symptoms in Patients With Tinnitus: International Web-Based Survey.Interactive journal of medical research · 2019Article
- Altered functional connectivity in binge eating disorder and bulimia nervosa: A resting-state fMRI study.Brain and behavior · 2019Article
- Bilateral Dorsomedial Prefrontal Cortex rTMS for Tinnitus Treatment: A Successful Case.The Eurasian journal of medicine · 2019Article
- Adjunctive Role of Bifrontal Transcranial Direct Current Stimulation in Distressed Patients with Severe Tinnitus.Journal of Korean medical science · 2019Article
- Pre-stimulus Brain Activity Is Associated With State-Anxiety Changes During Single-Session Transcranial Direct Current Stimulation.Frontiers in human neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Repetitive transcranial magnetic stimulation (rTMS) has been proposed as a tinnitus treatment option. Promising results have been obtained by consecutive stimulation of lateral frontal and auditory brain regions. We investigated a combined stimulation paradigm targeting the anterior cingulate cortex (ACC) with double cone coil rTMS, followed by stimulation of the temporo-parietal junction area with a figure-of-eight coil. The study was conducted as a randomized, double-blind pilot trial in 40 patients suffering from chronic tinnitus. We compared mediofrontal stimulation with double-cone-coil, (2000 stimuli, 10 Hz) followed by left temporo-parietal stimulation with figure-of-eight-coil (2000 stimuli, 1 Hz) to left dorsolateral-prefrontal-cortex stimulation with figure-of-eight-coil (2000 stimuli, 10 Hz) followed by temporo-parietal stimulation with figure-of-eight-coil (2000 stimuli, 1 Hz). The stimulation was feasible with comparable dropout rates in both study arms; no severe adverse events were registered. Responder rates did not differ in both study arms. There was a significant main effect of time for the change in the TQ score, but no significant time x group interaction. This pilot study demonstrated the feasibility of combined mediofrontal/temporoparietal-rTMS-stimulation with double cone coil in tinnitus patients but failed to show better outcome compared to an actively rTMS treated control group.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.